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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccn2tm1.1Vlcg
targeted mutation 1.1, Velocigene
MGI:4822056
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccn2tm1.1Vlcg/Ccn2tm1.1Vlcg involves: 129S6/SvEvTac * C57BL/6NTac MGI:5546252
cn2
 		Ccn2tm1.1Vlcg/Ccn2tm1.1Vlcg
Tg(Prrx1-cre)1Cjt/0 		involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac * SJL/J MGI:4822057
cn3
 		Ccn2tm1Mga/Ccn2tm1.1Vlcg
Tg(BGLAP-cre)1Clem/0 		involves: 129S6/SvEvTac * C57BL/6NTac * FVB/NJ MGI:4822058


Genotype
MGI:5546252
hm1
Allelic
Composition		 Ccn2tm1.1Vlcg/Ccn2tm1.1Vlcg
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccn2tm1.1Vlcg mutation (0 available); any Ccn2 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:4822057
cn2
Allelic
Composition		 Ccn2tm1.1Vlcg/Ccn2tm1.1Vlcg
Tg(Prrx1-cre)1Cjt/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccn2tm1.1Vlcg mutation (0 available); any Ccn2 mutation (29 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
decreased bone mineral density ( J:163027 )
• at 1 month of age osteopenia is seen in males but not females
abnormal trabecular bone morphology ( J:163027 )
• at 1 month of age the number of trabeculae is reduced in males but not females




Genotype
MGI:4822058
cn3
Allelic
Composition		 Ccn2tm1Mga/Ccn2tm1.1Vlcg
Tg(BGLAP-cre)1Clem/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NTac * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccn2tm1.1Vlcg mutation (0 available); any Ccn2 mutation (29 available)
Ccn2tm1Mga mutation (0 available); any Ccn2 mutation (29 available)
Tg(BGLAP-cre)1Clem mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
decreased bone mineral density ( J:163027 )
• at 1 month of age osteopenia is seen
• at 1 month of age the phenotype is similar to that in Ctgftm1Mga single homozygotes
• at 6 months of age males show a decrease in bone volume secondary to a decrease in trabecular number
abnormal trabecular bone morphology ( J:163027 )
• at 1 month and 6 months of age the number of trabeculae is reduced




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory