All Phenotypes Iqsec1<tm1.1Hck> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Iqsec1^tm1.1Hck
targeted mutation 1.1, Hans-Christian Kornau
MGI:4822241

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Iqsec1^tm1.1Hck/Iqsec1^tm1.1Hck	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:4822244

Allelic Composition	Iqsec1^tm1.1Hck/Iqsec1^tm1.1Hck
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Iqsec1^tm1.1Hck mutation (0 available); any Iqsec1 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent long-term depression ( J:163183 )

• CA1 neurons treated with a cre-expressing lentivirus fail to exhibit mGluR- or NMDAR-long term depression unlike in wild-type neurons

• Schaffer collaterals treated with a cre-expressing lentivirus fail to exhibit long term depression in response to low-frequency stimulation in the presence of mGluR antagonists unlike in similarly treated wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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