Phenotypes associated with this allele

• Allele Symbol: N6amt1^tm1Gxu
• Allele Name: targeted mutation 1, Guo-Liang Xu
• Allele ID: MGI:4822324
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	N6amt1^tm1Gxu/N6amt1^tm1Gxu	involves: 129S1/Sv * C57BL/6	MGI:4822357

Genotype
MGI:4822357

hm1

• Allelic Composition: N6amt1^tm1Gxu/N6amt1^tm1Gxu
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:163286 )

• mice die between E7.5 and E9.5

embryo

abnormal embryo development ( J:163286 )

• embryos are round in shape instead of elongated

decreased embryo size ( J:163286 )

failure of primitive streak formation ( J:163286 )

• at E6.5

inner cell mass degeneration ( J:163286 )

• after 9 days in culture, blastocysts exhibit slower outgrowth and inner cell mass cells are missing unlike in similarly treated wild-type blastocysts

• however, blastocyts exhibit normal inner cell masses after 4 and 6 days in culture

abnormal ectoplacental cone morphology ( J:163286 )

• the ectoplacental cone is under-developed compared to in wild-type mice

growth/size/body

decreased embryo size ( J:163286 )