Phenotypes associated with this allele

• Allele Symbol: Ltb4r2^tm1Bodd
• Allele Name: targeted mutation 1, Bodduluri Haribabu
• Allele ID: MGI:4822400
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ltb4r2^tm1Bodd/Ltb4r2^tm1Bodd	involves: 129S4/SvJaeSor * C57BL/6	MGI:4822410

Genotype
MGI:4822410

hm1

• Allelic Composition: Ltb4r2^tm1Bodd/Ltb4r2^tm1Bodd
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:163271 )

N • neutrophils exhibit normal migration in response to Ltb4

decreased susceptibility to induced arthritis ( J:163271 )

• in a K/BxN serum transfer model, mice exhibit reduced inflammation and bone erosion with no cartilage damage compared with similarly treated wild-type mice

• bone marrow protects engrafted wild-type mice against induced arthritis with reduced inflammation, bone erosion, and cartilage damage compared with similarly treated wild-type mice engrafted with wild-type bone marrow

skeleton

decreased susceptibility to induced arthritis ( J:163271 )

• in a K/BxN serum transfer model, mice exhibit reduced inflammation and bone erosion with no cartilage damage compared with similarly treated wild-type mice

• bone marrow protects engrafted wild-type mice against induced arthritis with reduced inflammation, bone erosion, and cartilage damage compared with similarly treated wild-type mice engrafted with wild-type bone marrow