Phenotypes associated with this allele

• Allele Symbol: Fcrla^tm1.1Cln
• Allele Name: targeted mutation 1.1, Marco Colonna
• Allele ID: MGI:4822412
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fcrla^tm1.1Cln/Fcrla^tm1.1Cln	involves: 129P2/OlaHsd * C57BL/6	MGI:4822418

Genotype
MGI:4822418

hm1

• Allelic Composition: Fcrla^tm1.1Cln/Fcrla^tm1.1Cln
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:163261 )

N • mice exhibit normal T-dependent and T-independent antibody responses and antibodies produced in antigen challenge tests are intact and functional

abnormal humoral immune response ( J:163261 )

• NP-Ficoll-treated mice develop serum antibodies faster than in similarly treated wild-type mice

• however, antibody isotypes at 7 days post-immunization are normal

increased IgG1 level ( J:163261 )

• mice secondarily challenged with sheep red blood cells (SRBCs) exhibit an increase in total IgG1 and anti-SRBC IgG1 compared with similarly treated wild-type mice

• however, response to primary SRBC challenge is normal

hematopoietic system

increased IgG1 level ( J:163261 )

• mice secondarily challenged with sheep red blood cells (SRBCs) exhibit an increase in total IgG1 and anti-SRBC IgG1 compared with similarly treated wild-type mice

• however, response to primary SRBC challenge is normal