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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
In(2a;Itch)18H
inversion, Chr 2, 18 Harwell
MGI:4822472
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
In(2a;Itch)18H/In(2a;Itch)18H involves: 101/H * C3H/HeH MGI:4822576


Genotype
MGI:4822576
hm1
Allelic
Composition
In(2a;Itch)18H/In(2a;Itch)18H
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
In(2a;Itch)18H mutation (1 available); any In(2a;Itch)18H mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological

pigmentation
• darker than the commonly known pigmentation umbrous (J:163587)

digestive/alimentary system

immune system
N
• activated T cells exhibit normal IL2 production
• large and often multinucleated
• cytoplasm appears laminated, infrequently containing large crystals
• erythroid progenitor cells predominate
• includes hyperplasia of follicles and distention of medullary sinusoids with plasma cells
• of the skin, especially the ears
• presumably due to scratching

integument
• darker than the commonly known pigmentation umbrous (J:163587)
• especially the ears

hematopoietic system
• large and often multinucleated
• cytoplasm appears laminated, infrequently containing large crystals
• erythroid progenitor cells predominate

homeostasis/metabolism
• associated with pulmonary chronic interstitial inflammation and alveolar proteinosis

mortality/aging
• severe immune disease results in death between 4 and 6 months of age attributed to hypoxia

respiratory system
• large and often multinucleated
• cytoplasm appears laminated, infrequently containing large crystals
• a variable minimal infiltrate of neutrophils is seen
• many line alveoli and are large containing clear cytoplasmic vacuoles





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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory