About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fndc3btm1Maim
targeted mutation 1, Masayoshi Imagawa
MGI:4822558
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fndc3btm1Maim/Fndc3btm1Maim B6.129S2-Fndc3btm1Maim MGI:4822564
hm2
 		Fndc3btm1Maim/Fndc3btm1Maim involves: 129S2/SvPas MGI:4822566


Genotype
MGI:4822564
hm1
Allelic
Composition		 Fndc3btm1Maim/Fndc3btm1Maim
Genetic
Background		 B6.129S2-Fndc3btm1Maim
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fndc3btm1Maim mutation (2 available); any Fndc3b mutation (151 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:163660 )
• all mice are dead by P1
• all mice delivered by caesarean section die within 15 minutes

cellular
abnormal cell adhesion ( J:163660 )
• mouse embryonic fibroblasts exhibit reduced cell adhesion and cell spreading with reduced stress fiber formation compared with wild-type cells
abnormal cell differentiation ( J:163660 )
• mouse embryonic fibroblasts exhibit reduced angiogenesis compared with wild-type cells
decreased fibroblast cell migration ( J:163660 )
• mouse embryonic fibroblasts in a wound healing assay exhibit reduced migration compared with wild-type cells
decreased fibroblast proliferation ( J:163660 )
• mouse embryonic fibroblasts

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:163660 )
N
• newborn mice exhibit normal energy homeostasis




Genotype
MGI:4822566
hm2
Allelic
Composition		 Fndc3btm1Maim/Fndc3btm1Maim
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fndc3btm1Maim mutation (2 available); any Fndc3b mutation (151 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell differentiation ( J:162425 )
• mouse embryonic fibroblasts (MEFs) transplanted into athymic mice develop into ossified tissues unlike similarly treated wild-type cells
• MEFs exhibit enhanced osteogenesis compared with wild-type cells
• MEFs exhibit impaired adipogenesis compared with wild-type cells

skeleton
increased bone ossification ( J:162425 )
• mouse embryonic fibroblasts (MEFs) transplanted into athymic mice develop into ossified tissues unlike similarly treated wild-type cells
• MEFs exhibit enhanced osteogenesis compared with wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory