Phenotypes associated with this allele

• Allele Symbol: Chdh^tm1Zei
• Allele Name: targeted mutation 1, Steven H Zeisel
• Allele ID: MGI:4822561
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chdh^tm1Zei/Chdh^tm1Zei	involves: 129P2/OlaHsd * C57BL/6	MGI:4822562

Genotype
MGI:4822562

hm1

• Allelic Composition: Chdh^tm1Zei/Chdh^tm1Zei
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

asthenozoospermia ( J:162343 )

♂ • diminished sperm motility

♂ • sperm counts are normal

reduced male fertility ( J:162343 )

♂ • only one of eleven homozygous males was able to reproduce

♂ • female mutant mice had no reproductive impairment

cellular

abnormal mitochondrial crista morphology ( J:162343 )

• mitochondria in the midpiece of the mutant sperm and skeletal muscle had malformed cristae and were enlarged/swollen compared that of wild type

dilated mitochondrion ( J:162343 )

• mitochondria in the midpiece of the mutant sperm and skeletal muscle are enlarged/swollen compared that of wild type

asthenozoospermia ( J:162343 )

♂ • diminished sperm motility

♂ • sperm counts are normal

abnormal respiratory electron transport chain ( J:162343 )

• ATP content, total mitochondrial dehydrogenase activity and inner mitochondrial membrane polarization were all significantly reduced in sperm from mutant mice