Phenotypes associated with this allele

• Allele Symbol: sims
• Allele Name: sexual reproduction organ, immaturity, and seizure
• Allele ID: MGI:4822565
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	sims/sims	B6.Cg-sims/GrsrJ	MGI:4822575
ht2	sims/sims^+	B6.Cg-sims/GrsrJ	MGI:4839534

Genotype
MGI:4822575

hm1

• Allelic Composition: sims/sims
• Genetic Background: B6.Cg-sims/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:161505 )

• homozygotes often die suddenly after handling or noise exposure

behavior/neurological

tremors ( J:161505 )

audiogenic seizures ( J:161505 )

• increased susceptibility to noise or handling induced seizures or death

growth/size/body

malocclusion ( J:161505 )

decreased body size ( J:161505 )

nervous system

audiogenic seizures ( J:161505 )

• increased susceptibility to noise or handling induced seizures or death

increased brain size ( J:161505 )

craniofacial

malocclusion ( J:161505 )

skeleton

malocclusion ( J:161505 )

reproductive system

small uterus ( J:161505 )

♀

abnormal reproductive system development ( J:161505 )

• smaller secondary sex organs, particularly the uterus

infertility ( J:161505 )

• neither male nor female homozygotes breed

female infertility ( J:161505 )

♀

male infertility ( J:161505 )

♂

Genotype
MGI:4839534

ht2

• Allelic Composition: sims/sims⁺
• Genetic Background: B6.Cg-sims/GrsrJ

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:161505 )

behavior/neurological

environmentally induced seizures ( J:161505 )

• increased susceptibility to noise or handling induced seizures or death

nervous system

environmentally induced seizures ( J:161505 )

• increased susceptibility to noise or handling induced seizures or death