About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(CMV-ATXN3*94Q)94Pama
transgene insertion 94, Patricia Maciel
MGI:4822570
Summary 2 genotypes


Genotype
MGI:4822572
tg1
Allelic
Composition		 Tg(CMV-ATXN3*94Q)94Pama/Tg(CMV-ATXN3*94Q)94Pama
Genetic
Background		 B6.FVB-Tg(CMV-ATXN3*94Q)94Pama
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:163032 )
N
• mice exhibit normal gait pattern and limb strength between 16 and 84 weeks of age
impaired coordination ( J:163032 )
• beginning at 16 weeks on a rotarod
• homozygous mice tend to spend less time on a rotarod than heterozygous mice
decreased locomotor activity ( J:163032 )
• mice exhibit a decrease of locomotor activity compared with wild-type mice

nervous system
astrocytosis ( J:163032 )
• at 49 weeks in the substantia nigra and vestibular nuclei
neurodegeneration ( J:163032 )
• at 16 weeks, mice exhibit mild neuronal atrophy in areas such as the pontine and dentate nuclei unlike wild-type mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Machado-Joseph disease DOID:1440 OMIM:109150
 J:163032




Genotype
MGI:4822571
tg2
Allelic
Composition		 Tg(CMV-ATXN3*94Q)94Pama/0
Genetic
Background		 B6.FVB-Tg(CMV-ATXN3*94Q)94Pama
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:163032 )
N
• mice exhibit normal gait pattern and limb strength between 16 and 84 weeks of age
impaired coordination ( J:163032 )
• beginning at 16 weeks on a rotarod
• heterozygous mice tend to spend more time on a rotarod than homozygous mice
decreased locomotor activity ( J:163032 )
• mice tend to exhibit a decrease of locomotor activity compared with wild-type mice

nervous system
nervous system phenotype ( J:163032 )
N
• mice do not exhibit intranuclear inclusions at 49 weeks
astrocytosis ( J:163032 )
• at 49 weeks in the substantia nigra and vestibular nuclei
neurodegeneration ( J:163032 )
• at 16 weeks, mice exhibit mild neuronal atrophy unlike wild-type mice

cellular
abnormal cell physiology ( J:163032 )
• mice exhibit generational instability and somatic mosaicism in CAG repeats of the transgene

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Machado-Joseph disease DOID:1440 OMIM:109150
 J:163032




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory