Phenotypes associated with this allele

• Allele Symbol: Mir144/Mir451a^tm1.1Mjwe
• Allele Name: targeted mutation 1.1, Mitchell J Weiss
• Allele ID: MGI:4829379
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir144/Mir451a^tm1.1Mjwe/Mir144/Mir451a^tm1.1Mjwe	Not Specified	MGI:4829383

Genotype
MGI:4829383

hm1

• Allelic Composition: Mir144/Mir451a^tm1.1Mjwe/Mir144/Mir451a^tm1.1Mjwe
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased cellular sensitivity to hydrogen peroxide ( J:163250 )

• lysis of erythrocytes

hematopoietic system

increased spleen weight ( J:163250 )

• twice as large as wild-type

spleen hyperplasia ( J:163250 )

• marked erythroid hyperplasia

anemia ( J:163250 )

• mild anemia

decreased hemoglobin content ( J:163250 )

decreased mean corpuscular hemoglobin ( J:163250 )

decreased mean corpuscular volume ( J:163250 )

increased red blood cell distribution width ( J:163250 )

• reticulocytosis with an increase in red cell distribution width (RDW), reflecting the size variation

increased number of Heinz bodies ( J:163250 )

• Heinz bodies, reflecting precipitated hemoglobin are present

polychromatophilia ( J:163250 )

• young red blood cells, with erythrocyte shape irregularities and occasional inclusions

reticulocytosis ( J:163250 )

homeostasis/metabolism

decreased catalase activity ( J:163250 )

• reduced catalase activity in erythrocytes

abnormal physiological response to xenobiotic ( J:163250 )

• in a methylcellulose colony assay the formation of burst-forming unit erythroid (BFU-e)-type colonies from mutant bone marrow progenitors is inhibited selectively by buthionine sulfoximine (BSO), a pro-oxidant that depletes cells of glutathione

• exhibit a more rapid and profound decreases in hematocrit levels and subsequent delayed recovery in response to phenylhydrazine,(PHZ), an oxidant that induces denaturation of hemoglobin, resulting in rapid erythrocyte destruction

immune system

increased spleen weight ( J:163250 )

• twice as large as wild-type

spleen hyperplasia ( J:163250 )

• marked erythroid hyperplasia

growth/size/body

increased spleen weight ( J:163250 )

• twice as large as wild-type

spleen hyperplasia ( J:163250 )

• marked erythroid hyperplasia