Phenotypes associated with this allele

• Allele Symbol: Mir451a^tm1Eno
• Allele Name: targeted mutation 1, Eric N Olson
• Allele ID: MGI:4829385
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir451a^tm1Eno/Mir451a^tm1Eno	involves: C57BL/6	MGI:4829387
ht2	Mir451a^tm1Eno/Mir451a^+	involves: C57BL/6	MGI:4829389

Genotype
MGI:4829387

hm1

• Allelic Composition: Mir451a^tm1Eno/Mir451a^tm1Eno
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged spleen ( J:163251 )

• increase in cellularity with hypercellular clusters of erythroid colonies

increased erythroid progenitor cell number ( J:163251 )

• in bone marrow and spleen

abnormal fetal derived definitive erythrocyte cell number ( J:163251 )

• fetal liver cells show a significant decrease in the most mature erythrocytes

• in vitro differentiation of 14.5 dpc fetal liver cells reveals a decrease in the most mature erythrocytes from cell suspensions

• increase in region II CD71+/TER119+ erythroblasts in bone marrow

immune system

enlarged spleen ( J:163251 )

• increase in cellularity with hypercellular clusters of erythroid colonies

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:163251 )

• a greater decrease in hematocrit in response to to phenylhydrazine hydrochloride-induced damage

growth/size/body

enlarged spleen ( J:163251 )

• increase in cellularity with hypercellular clusters of erythroid colonies

Genotype
MGI:4829389

ht2

• Allelic Composition: Mir451a^tm1Eno/Mir451a⁺
• Genetic Background: involves: C57BL/6

hematopoietic system

abnormal erythrocyte cell number ( J:163251 )

• 50% of wild-type levels of most mature erythrocytes