Phenotypes associated with this allele

• Allele Symbol: Mir144/Mir451a^tm1.2Doca
• Allele Name: targeted mutation 1.2, Donal O'Carroll
• Allele ID: MGI:4829618
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir144/Mir451a^tm1.2Doca/Mir144/Mir451a^tm1.2Doca	involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/cJ	MGI:4829624

Genotype
MGI:4829624

hm1

• Allelic Composition: Mir144/Mir451a^tm1.2Doca/Mir144/Mir451a^tm1.2Doca
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/cJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:163418 )

• phenylhydrazine-treated mice exhibit increased mortality compared with similarly treated wild-type mice

hematopoietic system

enlarged spleen ( J:163418 )

abnormal erythropoiesis ( J:163418 )

• terminal erythropoiesis is abnormal compared to in wild-type mice

• mice exhibit stress erythropoiesis

• bone marrow contains fewer mature orthochromatophilic erythroblasts compared to in wild-type mice

• numbers of mature orthochromatophilic erythroblasts in the spleen are slightly elevated to normal indicating loss of cells during late erythroid maturation

• phenylhydrazine-treated mice exhibit increased mortality compared with similarly treated wild-type mice

• bone marrow transplanted into wild-type mice confirms the abnormal erythropoiesis phenotype

anemia ( J:163418 )

• mild and compensated through stress erythropoiesis

increased erythroid progenitor cell number ( J:163418 )

• early erythroblasts are increased 10-fold in the spleen compared to in wild-type mice

decreased erythrocyte cell number ( J:163418 )

decreased hematocrit ( J:163418 )

decreased hemoglobin content ( J:163418 )

increased red blood cell distribution width ( J:163418 )

anisocytosis ( J:163418 )

immune system

enlarged spleen ( J:163418 )

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:163418 )

• phenylhydrazine-treated mice exhibit increased mortality compared with similarly treated wild-type mice

growth/size/body

enlarged spleen ( J:163418 )