Analysis Tools
immune system
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• in the bone marrow
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• B cell lymphopoiesis is arrested at the early pre-B cell stage
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• B220+CD43+ B and immature B cells in the bone marrow are decreased 300-fold compared to in wild-type mice
• however, the number of B220+CD43+ cells in the bone marrow is normal
• mice have fewer splenic CD19+ cells than wild-type mice
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• B220+CD43+ B and immature B cells in the bone marrow are decreased 300-fold compared to in wild-type mice
• however, the number of B220+CD43+ cells in the bone marrow is normal
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• mice lack CD45R/B220+ cells unlike wild-type mice
• lymph nodes or peritoneal lavages lack CD19+ cells unlike in wild-type mice
• however, mice transplanted with wild-type bone marrow exhibit B lymphopoiesis
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• 2-fold fewer CD3+ cells are found in the spleen compared to in wild-type mice
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small spleen
(
J:163412
)
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• mice fail to generate antibodies when challenged with an antigen unlike wild-type mice
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• mice lack serum immunoglobulin unlike wild-type mice
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hematopoietic system
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• in the bone marrow
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• B cell lymphopoiesis is arrested at the early pre-B cell stage
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• the ratio of myeloid to lymphoid cells is increased compared to in wild-type mice
• the Mac1+Gr+ compartment of the bone marrow is enlarged compared to in wild-type mice
• the number of myeloid/granulocitic/erythroid progenitors is increased compared to in wild-type mice
• however, total bone marrow and hematopoietic stem cell numbers are normal
|
|
• B220+CD43+ B and immature B cells in the bone marrow are decreased 300-fold compared to in wild-type mice
• however, the number of B220+CD43+ cells in the bone marrow is normal
• mice have fewer splenic CD19+ cells than wild-type mice
|
|
• B220+CD43+ B and immature B cells in the bone marrow are decreased 300-fold compared to in wild-type mice
• however, the number of B220+CD43+ cells in the bone marrow is normal
|
|
• mice lack CD45R/B220+ cells unlike wild-type mice
• lymph nodes or peritoneal lavages lack CD19+ cells unlike in wild-type mice
• however, mice transplanted with wild-type bone marrow exhibit B lymphopoiesis
|
|
• 2-fold fewer CD3+ cells are found in the spleen compared to in wild-type mice
|
small spleen
(
J:163412
)
|
• mice lack serum immunoglobulin unlike wild-type mice
|
neoplasm
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• 25% incidence of spontaneous carcinoma development with myoepithelial and basaloid differentiation in salivary glands in mutants over 6 months of age, resembling human basal cell adenocarcinoma with myoepithelial differentiation
• tumors develop proximate to submandibular glands and to a lesser extent in the sublingual and parotid glands
• exhibit central cavitary lesions filled with necrotic debris that are lined by tumor cells and contain a mixture of spindle cells interspersed with epitheloid cells and lesser basaloid to clear cell differentiation
• tumors show variable presence of high mitotic rate, pleomorphism (anisokaryosis and anisocytosis), and invasion into adjacent salivary glands
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endocrine/exocrine glands
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• 25% incidence of spontaneous carcinoma development with myoepithelial and basaloid differentiation in salivary glands in mutants over 6 months of age, resembling human basal cell adenocarcinoma with myoepithelial differentiation
• tumors develop proximate to submandibular glands and to a lesser extent in the sublingual and parotid glands
• exhibit central cavitary lesions filled with necrotic debris that are lined by tumor cells and contain a mixture of spindle cells interspersed with epitheloid cells and lesser basaloid to clear cell differentiation
• tumors show variable presence of high mitotic rate, pleomorphism (anisokaryosis and anisocytosis), and invasion into adjacent salivary glands
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digestive/alimentary system
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• 25% incidence of spontaneous carcinoma development with myoepithelial and basaloid differentiation in salivary glands in mutants over 6 months of age, resembling human basal cell adenocarcinoma with myoepithelial differentiation
• tumors develop proximate to submandibular glands and to a lesser extent in the sublingual and parotid glands
• exhibit central cavitary lesions filled with necrotic debris that are lined by tumor cells and contain a mixture of spindle cells interspersed with epitheloid cells and lesser basaloid to clear cell differentiation
• tumors show variable presence of high mitotic rate, pleomorphism (anisokaryosis and anisocytosis), and invasion into adjacent salivary glands
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growth/size/body
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• 25% incidence of spontaneous carcinoma development with myoepithelial and basaloid differentiation in salivary glands in mutants over 6 months of age, resembling human basal cell adenocarcinoma with myoepithelial differentiation
• tumors develop proximate to submandibular glands and to a lesser extent in the sublingual and parotid glands
• exhibit central cavitary lesions filled with necrotic debris that are lined by tumor cells and contain a mixture of spindle cells interspersed with epitheloid cells and lesser basaloid to clear cell differentiation
• tumors show variable presence of high mitotic rate, pleomorphism (anisokaryosis and anisocytosis), and invasion into adjacent salivary glands
|
craniofacial
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• 25% incidence of spontaneous carcinoma development with myoepithelial and basaloid differentiation in salivary glands in mutants over 6 months of age, resembling human basal cell adenocarcinoma with myoepithelial differentiation
• tumors develop proximate to submandibular glands and to a lesser extent in the sublingual and parotid glands
• exhibit central cavitary lesions filled with necrotic debris that are lined by tumor cells and contain a mixture of spindle cells interspersed with epitheloid cells and lesser basaloid to clear cell differentiation
• tumors show variable presence of high mitotic rate, pleomorphism (anisokaryosis and anisocytosis), and invasion into adjacent salivary glands
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| salivary gland cancer | DOID:8850 | J:197352 | ||
