Phenotypes associated with this allele

• Allele Symbol: Myh9^{tm3(GFP/MYH9/MYH10)Rsad}
• Allele Name: targeted mutation 3, Robert S Adelstein
• Allele ID: MGI:4829690
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myh9^tm3(GFP/MYH9/MYH10)Rsad/Myh9^tm3(GFP/MYH9/MYH10)Rsad	involves: 129S4/SvJae * C57BL/6	MGI:4829694

Genotype
MGI:4829694

hm1

• Allelic Composition: Myh9^{tm3(GFP/MYH9/MYH10)Rsad}/Myh9^{tm3(GFP/MYH9/MYH10)Rsad}
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:163702 )

• die between E11.5 and E12.5

embryo

embryo phenotype ( J:163702 )

N • unlike null mice, knock in embryos undergo gastrulation

abnormal placental labyrinth vasculature morphology ( J:163702 )

• invasion of embryonic blood vessels is impaired

• decrease in the internal space of fetal and maternal vessels

abnormal vitelline vasculature morphology ( J:163702 )

• fewer visible vessels at E9.5 and E10.5

thin placenta labyrinth ( J:163702 )

• thinner compared to controls

pale yolk sac ( J:163702 )

cellular

abnormal actin cytoskeleton morphology ( J:163702 )

• in MEFs actin filaments are thin, disorganized and often fail to align with the direction of migration

abnormal cell adhesion ( J:163702 )

• fewer and smaller focal adhesions are detected in MEFs and the stress fibers in the focal adhesions are in disarray

abnormal cell migration ( J:163702 )

• in a wound healing assay MEFs close the wound more rapidly compared to wild-type controls

• a transwell assay indicates that directional cell migration is impaired in MEFs

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:163702 )

• invasion of embryonic blood vessels is impaired

• decrease in the internal space of fetal and maternal vessels

abnormal vitelline vasculature morphology ( J:163702 )

• fewer visible vessels at E9.5 and E10.5