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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Myh9tm4(GFP/MYH10/MYH9)Rsad
targeted mutation 4, Robert S Adelstein
MGI:4829691
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Myh9tm4(GFP/MYH10/MYH9)Rsad/Myh9tm4(GFP/MYH10/MYH9)Rsad involves: 129S4/SvJae * C57BL/6 MGI:4829695


Genotype
MGI:4829695
hm1
Allelic
Composition
Myh9tm4(GFP/MYH10/MYH9)Rsad/Myh9tm4(GFP/MYH10/MYH9)Rsad
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh9tm4(GFP/MYH10/MYH9)Rsad mutation (1 available); any Myh9 mutation (219 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
N
• unlike null mice, knock in embryos undergo gastrulation
• fewer visible vessels at E9.5 and E10.5
• placentas are composed predominantly of clusters of cuboidal trophoblasts
• the spongiotrophoblast layer is difficult to discern
• the labyrinth layer is difficult to discern
• embryonic blood vessels fail to invade the labyrinth layer
• thinner and more compact compared to controls
• at E9.5 and E10.5

cellular
• in MEFs actin filaments are thin, disorganized and often fail to align with the direction of migration
• fewer and smaller focal adhesions are detected in MEFs and the stress fibers in the focal adhesions are in disarray
• a transwell assay indicates that directional cell migration is impaired in MEFs
• however, the speed at which MEFs close a wound is similar to that of wild-type cells

cardiovascular system
• embryonic blood vessels fail to invade the labyrinth layer
• fewer visible vessels at E9.5 and E10.5





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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory