Phenotypes associated with this allele

• Allele Symbol: Glg1^tm1Brle
• Allele Name: targeted mutation 1, Brendan Lee
• Allele ID: MGI:4829764
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Glg1^tm1Brle/Glg1^tm1Brle	involves: 129S7/SvEvBrd * C57BL/6J	MGI:4829778
cx2	Fgfr3^tm1Led/Fgfr3^tm1Led Glg1^tm1Brle/Glg1^tm1Brle	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J	MGI:4829779

Genotype
MGI:4829778

hm1

• Allelic Composition: Glg1^tm1Brle/Glg1^tm1Brle
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

decreased long bone epiphyseal plate size ( J:163721 )

• mice exhibit decreased growth plates in the femur affecting both the proliferative and hypertrophic regions with decreased chondrocyte cell density and increased extracellular matrix deposition compared to in wild-type mice

small thoracic cage ( J:163721 )

• narrow

abnormal bone structure ( J:163721 )

• all bony elements are shorter and thinner than in wild-type mice

abnormal skeleton physiology ( J:163721 )

• extracellular matrix deposition in the epiphyseal growth plate is increased compared to in wild-type mice

abnormal chondrocyte physiology ( J:163721 )

• chondrocyte proliferation is decreased compared to in wild-type mice

growth/size/body

decreased birth body size ( J:163721 )

decreased body size ( J:163721 )

• at 4 weeks

decreased fetal size ( J:163721 )

• from E14.5 onward

Genotype
MGI:4829779

cx2

• Allelic Composition: Fgfr3^tm1Led/Fgfr3^tm1Led; Glg1^tm1Brle/Glg1^tm1Brle
• Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

skeleton

decreased long bone epiphyseal plate size ( J:163721 )

• mice exhibit decreased growth plates in the femur affecting both the proliferative and hypertrophic compared to in wild-type mice

growth/size/body

decreased body size ( J:163721 )

• at 4 weeks