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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mapk8ip1tm3.1Rjd
targeted mutation 3.1, Roger J Davis
MGI:4829783
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mapk8ip1tm3.1Rjd/Mapk8ip1tm3.1Rjd B6.129S6-Mapk8ip1tm3.1Rjd MGI:4829843


Genotype
MGI:4829843
hm1
Allelic
Composition
Mapk8ip1tm3.1Rjd/Mapk8ip1tm3.1Rjd
Genetic
Background
B6.129S6-Mapk8ip1tm3.1Rjd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk8ip1tm3.1Rjd mutation (1 available); any Mapk8ip1 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• in mice fed a high fat diet
• whether mice are fed a standard or high fat diet
• during hyperinsulinemic-euglycemic clamp studies, mice fed a normal or high fat diet exhibit increased insulin-mediated suppression of hepatic glucose production compared with similarly treated wild-type mice
• however, basal hepatic glucose production is normal
• when mice are fed a high fat diet, insulin-induced disposal of blood glucose is increased compared to in similarly treated wild-type mice
• mice fed a high fat diet exhibit greater steady-state glucose infusion rates during hyperinsulinemic-euglycemic clamp studies compared with similarly treated wild-type mice
• mice fed a high fat diet exhibit less increase in liver triglyceride compared with similarly treated wild-type mice

liver/biliary system
• mice fed a high fat diet exhibit reduced morphological changes, increase in mass, and accumulation of triglycerides compared with wild-type mice
• mice fed a high fat diet exhibit less increase in liver triglyceride compared with similarly treated wild-type mice
• mice fed a high fat diet exhibit less increase in liver mass compared with similarly treated wild-type mice

behavior/neurological
• modestly in mice fed a high fat diet





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory