Phenotypes associated with this allele

• Allele Symbol: Foxp1^tm2.1Eem
• Allele Name: targeted mutation 2.1, Edward E Morrisey
• Allele ID: MGI:4829787
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Foxp1^tm2.1Eem/Foxp1^tm2.1Eem Nkx2-5^tm1(cre)Rjs/Nkx2-5^+	involves: 129 * C57BL/6 * SJL	MGI:4829788
cn2	Foxp1^tm2.1Eem/Foxp1^tm2.1Eem Tg(Tek-cre)1Ywa/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:4829789

Genotype
MGI:4829788

cn1

• Allelic Composition: Foxp1^tm2.1Eem/Foxp1^tm2.1Eem; Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺
• Genetic Background: involves: 129 * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:163662 )

cardiovascular system

abnormal heart development ( J:163662 )

• expression analysis in cardiomyocytes indicates disruption of sarcomere structure and an inhibition of cardiomyocyte maturation

double outlet right ventricle ( J:163662 )

• at E14.5

thick interventricular septum ( J:163662 )

• by E16.5

ventricular septal defect ( J:163662 )

• at E14.5 ventricular septal defects are present; however, by E16.5 most mice do not have septal defects suggesting a delay in septal development

thick ventricular wall ( J:163662 )

• by E16.5 both the right and left ventricle walls are thicker compared to controls

increased fetal cardiomyocyte proliferation ( J:163662 )

• increased proliferation that is most prominent in the trabecular layer at E14.5 and E16.5

muscle

increased fetal cardiomyocyte proliferation ( J:163662 )

• increased proliferation that is most prominent in the trabecular layer at E14.5 and E16.5

abnormal sarcomere morphology ( J:163662 )

• expression analysis in cardiomyocytes indicates disruption of sarcomere structure

cellular

increased fetal cardiomyocyte proliferation ( J:163662 )

• increased proliferation that is most prominent in the trabecular layer at E14.5 and E16.5

Genotype
MGI:4829789

cn2

• Allelic Composition: Foxp1^tm2.1Eem/Foxp1^tm2.1Eem; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:163662 )

• die between E14.5 and E16.5

cardiovascular system

cardiovascular system phenotype ( J:163662 )

N • despite cre expression patterns, coronary vessel development is relatively unperturbed

abnormal cardiac outflow tract development ( J:163662 )

• thickened outflow tract at E14.5

• however, outflow tract septation is normal

increased atrioventricular cushion size ( J:163662 )

• thickened at E14.5

ventricular septal defect ( J:163662 )

• ventricular septal defect at E14.5

thin ventricular wall ( J:163662 )

• display minor ventricular thinning at E12.4

• by E14.5 most mice show extensive ventricular thinning

abnormal fetal cardiomyocyte proliferation ( J:163662 )

• significant reduction in proliferation in the compact zone myocardium and the trabecular myocardium at E12.5

muscle

abnormal fetal cardiomyocyte proliferation ( J:163662 )

• significant reduction in proliferation in the compact zone myocardium and the trabecular myocardium at E12.5

cellular

abnormal fetal cardiomyocyte proliferation ( J:163662 )

• significant reduction in proliferation in the compact zone myocardium and the trabecular myocardium at E12.5