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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dok3tm1Brs
targeted mutation 1, Brian Seed
MGI:4829861
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dok3tm1Brs/Dok3tm1Brs involves: C57BL/6 MGI:4829894
cx2
 		Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam
Dok3tm1Brs/Dok3tm1Brs 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:4829896


Genotype
MGI:4829894
hm1
Allelic
Composition		 Dok3tm1Brs/Dok3tm1Brs
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok3tm1Brs mutation (0 available); any Dok3 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased macrophage cell number ( J:163407 )
• abnormal Mac-2-positive macrophages in the lung

immune system
increased macrophage cell number ( J:163407 )
• abnormal Mac-2-positive macrophages in the lung




Genotype
MGI:4829896
cx2
Allelic
Composition		 Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam
Dok3tm1Brs/Dok3tm1Brs
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Yyam mutation (0 available); any Dok1 mutation (19 available)
Dok2tm1Yyam mutation (0 available); any Dok2 mutation (16 available)
Dok3tm1Brs mutation (0 available); any Dok3 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:163407 )
• nearly half (15 of 33) of the mice died between 14?51 weeks after birth

neoplasm
increased tumor incidence ( J:163407 )
• a markedly high incidence (24 of 41) of large cell tumors at 65 weeks of age
increased histiocytic sarcoma incidence ( J:163407 )
• abnormal proliferative cells with histiocytic morphology and cell surface markers in the bone marrow, spleen, and/or liver
• the histiocytic sarcoma is highly invasive and transplantable

hematopoietic system
increased macrophage cell number ( J:163407 )
• abnormal Mac-2-positive macrophages in the lung
abnormal macrophage physiology ( J:163407 )
• bone marrow-derived macrophages at 10-12 weeks of age stimulated with M-CSF and GM-CSF, show an increased proliferative response

immune system
increased macrophage cell number ( J:163407 )
• abnormal Mac-2-positive macrophages in the lung
abnormal macrophage physiology ( J:163407 )
• bone marrow-derived macrophages at 10-12 weeks of age stimulated with M-CSF and GM-CSF, show an increased proliferative response




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory