Phenotypes associated with this allele

• Allele Symbol: Del(6Slco1b2-Slco1a5)1Nki
• Allele Name: deletion, Chr 6, The Netherlands Cancer Institute
• Allele ID: MGI:4830091
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Del(6Slco1b2-Slco1a5)1Nki/+	involves: 129P2/OlaHsd * C57BL/6	MGI:4830142

Genotype
MGI:4830142

ht1

• Allelic Composition: Del(6Slco1b2-Slco1a5)1Nki/+
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal blood homeostasis ( J:163765 )

increased circulating bilirubin level ( J:163765 )

• total bilirubin levels in the plasma is increased 40-fold compared to in wild-type mice

• levels of bilirubin conjugated to glucoronide and unconjugated bile acids are increased compared to in wild-type mice

increased circulating HDL cholesterol level ( J:163765 )

increased circulating triglyceride level ( J:163765 )

increased bile salt level ( J:163765 )

• total bile acid in the plasma is increased 4-fold compared to in wild-type mice

abnormal urine homeostasis ( J:163765 )

• mice excrete the entire dose of methotrexate (MTX) unlike wild-type mice that excrete only 40% of the dose

decreased urine protein level ( J:163765 )

bilirubinuria ( J:163765 )

• urinary excretion of bilirubin is detected unlike in wild-type mice

abnormal xenobiotic pharmacokinetics ( J:163765 )

• methotrexate (MTX) levels in the small intestine are decreased 16.6-fold compared to in wild-type mice

• liver accumulation of MTX and fexofenadine ([H3]FEX) is decreased compared to in wild-type mice

• MTX levels in the plasma, kidney, brain, and spleen are increased compared to in wild-type mice

• mice excrete the entire dose of MTX unlike wild-type mice that excrete only 20% of the dose

• 2% of the MTX dose ends up in the feces compared with 20% in wild-type mice

• upon rifampicin treatment, liver MTX and 7OH-MTX levels are reduced to a greater extent than in similarly treated wild-type mice

• plasma concentrations of [H3]FEX are increased compared to in wild-type mice

• however, intestinal absorption of MTX is normal

liver/biliary system

abnormal bile secretion ( J:163765 )

• biliary secretion is half that of wild-type mice

• however, total bile acid pool size is normal

jaundice ( J:163765 )

renal/urinary system

abnormal urine homeostasis ( J:163765 )

• mice excrete the entire dose of methotrexate (MTX) unlike wild-type mice that excrete only 40% of the dose

decreased urine protein level ( J:163765 )

bilirubinuria ( J:163765 )

• urinary excretion of bilirubin is detected unlike in wild-type mice

growth/size/body

increased body weight ( J:163765 )

• in male and female mice between 9 and 14 weeks of age