Phenotypes associated with this allele

• Allele Symbol: Otulin^m3Sapc
• Allele Name: mutation 3, Sabine Cordes
• Allele ID: MGI:4830117
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Otulin^m3Sapc/Otulin^m3Sapc	C57BL/6J-Otulin^m3Sapc	MGI:4829973

Genotype
MGI:4829973

hm1

• Allelic Composition: Otulin^m3Sapc/Otulin^m3Sapc
• Genetic Background: C57BL/6J-Otulin^m3Sapc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:197674 )

• die between E12.5 and E14

nervous system

abnormal brain vasculature morphology ( J:197674 )

• branching vascular networks of the head and trunk are improperly organized

• large cranial vessels are dilated

• branching of cranial vessels is reduced

abnormal facial nerve morphology ( J:163657 )

• the facial nerve consistently shows abnormal "sprouting" or "branching" in 10.5 dpc embryos

abnormal vestibulocochlear nerve morphology ( J:163657 )

• the acoustic nerve consistently shows abnormal "sprouting" or "branching" in 10.5 dpc embryos

cardiovascular system

abnormal blood vessel morphology ( J:197674 )

• less elaborate vessel extensions between the somites in the trunk

abnormal internal carotid artery morphology ( J:197674 )

• decreased secondary and tertiary branching off of the internal carotid artery at E10.5

• larger dilated internal carotid arteries than in controls

abnormal brain vasculature morphology ( J:197674 )

• branching vascular networks of the head and trunk are improperly organized

• large cranial vessels are dilated

• branching of cranial vessels is reduced

abnormal vascular endothelial cell migration ( J:197674 )

• endothelial cells of cranial vessels tend to accumulate at branch points

craniofacial

micrognathia ( J:163657 )

• at 12.5-13.5 dpc the lower jaw is severely reduced

small pharyngeal arch ( J:197674 )

• reduced in size

skeleton

micrognathia ( J:163657 )

• at 12.5-13.5 dpc the lower jaw is severely reduced

hematopoietic system

abnormal hematopoietic system morphology/development ( J:163657 )

• at 12.5-13.5 dpc the blood is largely absent

cellular

abnormal vascular endothelial cell migration ( J:197674 )

• endothelial cells of cranial vessels tend to accumulate at branch points

embryo

small pharyngeal arch ( J:197674 )

• reduced in size

growth/size/body

microcephaly ( J:163657 )

• at 12.5-13.5 dpc the head appears smaller