Analysis Tools
vision/eye
|
• retinal degeneration is evident at 120 days of age by fundus examination and histology reveals significant loss of photoreceptor nuclei at 31 days of age and progressive loss thereafter although the loss at 47 days of age is not as severe as in the retinal degeneration 11 homozygotes
• transmission electron microscopy of retinas at 26 days of age shows thinning of the outer nuclear layer and that the photoreceptor nuclei are less ordered than in C57BL/6J controls
|
|
• fundus examination reveals clear retinal degeneration at 120 days of age
|
|
• electroretinograms show a reduced dark-adapted alpha wave at 3 weeks of age which flattens out by 5 weeks of age, and a light-adapted response that is normal at 3 weeks of age but significantly reduced by 4 and 5 weeks of age
|
homeostasis/metabolism
|
• decreased retinal dipalmitoylphospatidylcholine, platelet activating factor C16 and lyso-platelet activating factor C16
|
nervous system
|
• retinal degeneration is evident at 120 days of age by fundus examination and histology reveals significant loss of photoreceptor nuclei at 31 days of age and progressive loss thereafter although the loss at 47 days of age is not as severe as in the retinal degeneration 11 homozygotes
• transmission electron microscopy of retinas at 26 days of age shows thinning of the outer nuclear layer and that the photoreceptor nuclei are less ordered than in C57BL/6J controls
|
