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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Eif4etm1.1Lfur
targeted mutation 1.1, Luc Furic
MGI:4830310
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Eif4etm1.1Lfur/Eif4etm1.1Lfur involves: 129X1/SvJ MGI:4830312
cn2
 		Eif4etm1.1Lfur/Eif4etm1.1Lfur
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(Pbsn-cre)4Prb/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 MGI:4830313


Genotype
MGI:4830312
hm1
Allelic
Composition		 Eif4etm1.1Lfur/Eif4etm1.1Lfur
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif4etm1.1Lfur mutation (0 available); any Eif4e mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:163589 )
• mouse embryonic fibroblasts exposed to RAS-induced transformation exhibit 4- to 10-fold fewer colonies than similarly treated wild-type cells
• however, cell proliferation is normal




Genotype
MGI:4830313
cn2
Allelic
Composition		 Eif4etm1.1Lfur/Eif4etm1.1Lfur
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif4etm1.1Lfur mutation (0 available); any Eif4e mutation (42 available)
Ptentm2.1Ppp mutation (0 available); any Pten mutation (88 available)
Tg(Pbsn-cre)4Prb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor incidence ( J:163589 )
• at 7 months, mice exhibit fewer incidence of high grade prostate intraepithelial neoplasia due to delayed onset and decreased cell proliferation compared with Ptentm2.1Ppp/Ptentm2.1Ppp Tg(Pbsn-cre)4Prb mice
• mice do not exhibit infiltrating adenocarcinoma in the prostate unlike Ptentm2.1Ppp/Ptentm2.1Ppp Tg(Pbsn-cre)4Prb mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory