About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Smad4tm1.1Rdp
targeted mutation 1.1, Ronald DePinho
MGI:4830314
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Smad4tm1Rdp/Smad4tm1.1Rdp
Trim33tm1.1Los/Trim33tm1.2Los
Tg(CAG-cre)13Miya/0 		involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * SJL MGI:4830328
cn2
 		Smad4tm1Rdp/Smad4tm1.1Rdp
Tg(CAG-cre)13Miya/0 		involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * SJL MGI:4830329


Genotype
MGI:4830328
cn1
Allelic
Composition		 Smad4tm1Rdp/Smad4tm1.1Rdp
Trim33tm1.1Los/Trim33tm1.2Los
Tg(CAG-cre)13Miya/0
Genetic
Background		 involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad4tm1.1Rdp mutation (0 available); any Smad4 mutation (47 available)
Smad4tm1Rdp mutation (0 available); any Smad4 mutation (47 available)
Tg(CAG-cre)13Miya mutation (1 available)
Trim33tm1.1Los mutation (0 available); any Trim33 mutation (71 available)
Trim33tm1.2Los mutation (0 available); any Trim33 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal embryo development ( J:163858 )
• identical to mice null for Smad4 alone
absent anterior visceral endoderm ( J:163858 )
• not induced at E5.5




Genotype
MGI:4830329
cn2
Allelic
Composition		 Smad4tm1Rdp/Smad4tm1.1Rdp
Tg(CAG-cre)13Miya/0
Genetic
Background		 involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad4tm1.1Rdp mutation (0 available); any Smad4 mutation (47 available)
Smad4tm1Rdp mutation (0 available); any Smad4 mutation (47 available)
Tg(CAG-cre)13Miya mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal embryo development ( J:163858 )
• stated to phenocopy mice homozygous for Smad4tm1Cxd
absent anterior visceral endoderm ( J:163858 )
• not induced at E5.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory