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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Smad4tm1.1Rdp
targeted mutation 1.1, Ronald DePinho
MGI:4830314
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Smad4tm1Rdp/Smad4tm1.1Rdp
Trim33tm1.1Los/Trim33tm1.2Los
Tg(CAG-cre)13Miya/0 		involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * SJL MGI:4830328
cn2
 		Smad4tm1Rdp/Smad4tm1.1Rdp
Tg(CAG-cre)13Miya/0 		involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * SJL MGI:4830329


Genotype
MGI:4830328
cn1
Allelic
Composition		 Smad4tm1Rdp/Smad4tm1.1Rdp
Trim33tm1.1Los/Trim33tm1.2Los
Tg(CAG-cre)13Miya/0
Genetic
Background		 involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad4tm1.1Rdp mutation (0 available); any Smad4 mutation (48 available)
Smad4tm1Rdp mutation (0 available); any Smad4 mutation (48 available)
Tg(CAG-cre)13Miya mutation (1 available)
Trim33tm1.1Los mutation (0 available); any Trim33 mutation (71 available)
Trim33tm1.2Los mutation (0 available); any Trim33 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal embryo development ( J:163858 )
• identical to mice null for Smad4 alone
absent anterior visceral endoderm ( J:163858 )
• not induced at E5.5




Genotype
MGI:4830329
cn2
Allelic
Composition		 Smad4tm1Rdp/Smad4tm1.1Rdp
Tg(CAG-cre)13Miya/0
Genetic
Background		 involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad4tm1.1Rdp mutation (0 available); any Smad4 mutation (48 available)
Smad4tm1Rdp mutation (0 available); any Smad4 mutation (48 available)
Tg(CAG-cre)13Miya mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal embryo development ( J:163858 )
• stated to phenocopy mice homozygous for Smad4tm1Cxd
absent anterior visceral endoderm ( J:163858 )
• not induced at E5.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory