All Phenotypes Trim33<tm1.2Los> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Trim33^tm1.2Los
targeted mutation 1.2, Regine Losson
MGI:4830323

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim33^tm1.2Los/Trim33^tm1.2Los	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:4830327
cn2	Tg(CAG-cre)13Miya/0 Trim33^tm1.1Los/Trim33^tm1.2Los	involves: 129 * 129S2/SvPas * C57BL/6 * SJL	MGI:4830330
cn3	Trim33^tm1.1Los/Trim33^tm1.2Los Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129S2/SvPas * C57BL/6 * CBA * SJL	MGI:4830326
cn4	Smad4^tm1Rdp/Smad4^tm1.1Rdp Trim33^tm1.1Los/Trim33^tm1.2Los Tg(CAG-cre)13Miya/0	involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * SJL	MGI:4830328
cx5	Nodal^tm1Rob/Nodal^tm2Rob Trim33^tm1.2Los/Trim33^tm1.2Los	involves: 129S/SvEv * 129S2/SvPas * C57BL/6	MGI:4830331
cx6	Nodal^tm1Rob/Nodal⁺ Trim33^tm1.2Los/Trim33^tm1.2Los	involves: 129S/SvEv * 129S2/SvPas * C57BL/6	MGI:4830333

Allelic Composition	Trim33^tm1.2Los/Trim33^tm1.2Los
Genetic Background	involves: 129S2/SvPas * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trim33^tm1.2Los mutation (0 available); any Trim33 mutation (71 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:163858 )

• embryos are not recovered after E7.5

embryo

abnormal developmental patterning ( J:163858 )

• defects in embryonic polarity and tissue patterning at E6.5

abnormal mesoderm development ( J:163858 )

• defect in mesoderm formation

decreased embryo size ( J:163858 )

• at E6.5

failure of primitive streak formation ( J:163858 )

• absent at E6.5

abnormal embryonic-extraembryonic boundary morphology ( J:163858 )

• lack a clear distinction between the epiblast and extraembryonic ectoderm

absent extraembryonic ectoderm ( J:163858 )

• expression analysis indicates absence of extraembryonic ectoderm at E5.5

abnormal proamniotic cavity morphology ( J:163858 )

• at E6.5 the proamniotic cavity is undivided

abnormal anterior visceral endoderm morphology ( J:163858 )

• abnormally broad at E5.5

• at E6.5 markers of the AVE are expanded around the epiblast

growth/size/body

decreased embryo size ( J:163858 )

• at E6.5

Allelic Composition	Tg(CAG-cre)13Miya/0 Trim33^tm1.1Los/Trim33^tm1.2Los
Genetic Background	involves: 129 * 129S2/SvPas * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-cre)13Miya mutation (1 available)
Trim33^tm1.1Los mutation (0 available); any Trim33 mutation (71 available)
Trim33^tm1.2Los mutation (0 available); any Trim33 mutation (71 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryo development ( J:163858 )

• stated to be indistinguishable from mice homozygous for Trim33^tm1.2Ros

abnormal anterior visceral endoderm morphology ( J:163858 )

• expanded at E5.5

Allelic Composition	Trim33^tm1.1Los/Trim33^tm1.2Los Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (42 available)
Trim33^tm1.1Los mutation (0 available); any Trim33 mutation (71 available)
Trim33^tm1.2Los mutation (0 available); any Trim33 mutation (71 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, incomplete penetrance ( J:163858 )

• few embryos survive to E10

embryo

embryo phenotype ( J:163858 )

N	• unlike in homozygous germline null mice, no defects are seen in the anterior visceral endoderm or the extraembryonic ectoderm

abnormal endoderm development ( J:163858 )

• expression analysis indicates an almost radial expansion of the definitive endoderm at E7.5

abnormal mesendoderm development ( J:163858 )

• duplications of anterior axial mesendoderm tissues

decreased embryo size ( J:163858 )

• seen in about 1/3 of embryos that also have a defect in primitive streak morphology

incomplete rostral neuropore closure ( J:163858 )

• at E10 the few surviving embryos display open neural folds

abnormal primitive node morphology ( J:163858 )

• expanded in surviving embryos at E8.0

• duplications of node tissues

abnormal primitive streak elongation ( J:163858 )

• about 1/3 of embryos lack an overtly elongated streak

nervous system

incomplete rostral neuropore closure ( J:163858 )

• at E10 the few surviving embryos display open neural folds

abnormal brain development ( J:163858 )

• at E10 the few surviving embryos display defective brain development

growth/size/body

decreased embryo size ( J:163858 )

• seen in about 1/3 of embryos that also have a defect in primitive streak morphology

Allelic Composition	Smad4^tm1Rdp/Smad4^tm1.1Rdp Trim33^tm1.1Los/Trim33^tm1.2Los Tg(CAG-cre)13Miya/0
Genetic Background	involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad4^tm1.1Rdp mutation (0 available); any Smad4 mutation (44 available)
Smad4^tm1Rdp mutation (0 available); any Smad4 mutation (44 available)
Tg(CAG-cre)13Miya mutation (1 available)
Trim33^tm1.1Los mutation (0 available); any Trim33 mutation (71 available)
Trim33^tm1.2Los mutation (0 available); any Trim33 mutation (71 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryo development ( J:163858 )

• identical to mice null for Smad4 alone

absent anterior visceral endoderm ( J:163858 )

• not induced at E5.5

Allelic Composition	Nodal^tm1Rob/Nodal^tm2Rob Trim33^tm1.2Los/Trim33^tm1.2Los
Genetic Background	involves: 129S/SvEv * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nodal^tm1Rob mutation (2 available); any Nodal mutation (42 available)
Nodal^tm2Rob mutation (0 available); any Nodal mutation (42 available)
Trim33^tm1.2Los mutation (0 available); any Trim33 mutation (71 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:163858 )

N	• at E6.25 decrease in Nodal expression rescues patterning defects in the anterior visceral endoderm, extraembryonic ectoderm and mesoderm and the decrease in embryo size that are seen in Trim33 single homozygotes

Allelic Composition	Nodal^tm1Rob/Nodal⁺ Trim33^tm1.2Los/Trim33^tm1.2Los
Genetic Background	involves: 129S/SvEv * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nodal^tm1Rob mutation (2 available); any Nodal mutation (42 available)
Trim33^tm1.2Los mutation (0 available); any Trim33 mutation (71 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:163858 )

N	• the decrease in Nodal expression rescues patterning defects in the extraembryonic ectoderm and mesoderm and the decrease in embryo size that are seen in Trim33 single homozygotes

expanded anterior visceral endoderm ( J:163858 )

• expanded at E6.25

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