Phenotypes associated with this allele

• Allele Symbol: Reck^tm1.1Noda
• Allele Name: targeted mutation 1.1, Makoto Noda
• Allele ID: MGI:4830337
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Reck^tm1.1Noda/Reck^tm2.2Noda	involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj	MGI:5428662
cn2	Reck^tm1Ito/Reck^tm1.1Noda Tg(CAG-cre/Esr1*)5Amc/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:4830343

Genotype
MGI:5428662

ht1

• Allelic Composition: Reck^tm1.1Noda/Reck^tm2.2Noda
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal limb morphology ( J:184585 )

• with multiple cutaneous horns on the dorsal side of the extremities

abnormal limb bud morphology ( J:184585 )

• as early as E12.5 in the forelimb buds

• the posterior side is hypoplastic

• poor chondrocyte condensation

• increased cell density in the central area and uneven, spongy distribution of cells in the marginal areas

• hypoplastic without an increase in apoptosis

• the dorsal ectoderm cells exhibit altered appearance

abnormal apical ectodermal ridge morphology ( J:184585 )

• flattened

abnormal digit morphology ( J:184585 )

• fingertip bones are round and porous in all limbs

abnormal forelimb morphology ( J:184585 )

• in some mice one or both of the forelimbs are pointing backwards

• mice exhibit loss of postaxial forelimb structures with variable severity

• more severe in the right forelimb

absent ulna ( J:184585 )

• in some mice with forelimb pointing backward

embryo

abnormal limb bud morphology ( J:184585 )

• as early as E12.5 in the forelimb buds

• the posterior side is hypoplastic

• poor chondrocyte condensation

• increased cell density in the central area and uneven, spongy distribution of cells in the marginal areas

• hypoplastic without an increase in apoptosis

• the dorsal ectoderm cells exhibit altered appearance

abnormal apical ectodermal ridge morphology ( J:184585 )

• flattened

skeleton

absent ulna ( J:184585 )

• in some mice with forelimb pointing backward

Genotype
MGI:4830343

cn2

• Allelic Composition: Reck^tm1Ito/Reck^tm1.1Noda; Tg(CAG-cre/Esr1*)5Amc/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:163845 )

• mice treated with tamoxifen at E11 die after E15.5

cardiovascular system

abnormal blood vessel morphology ( J:163845 )

• at E15.5, blood vessels in tamoxifen-treated mice are large and irregularly shaped compared to in wild-type mice

abnormal brain vasculature morphology ( J:163845 )

• brain vasculature in tamoxifen-treated mice is disorganized and interrupted by large spaces and cavities unlike in wild-type mice

abnormal liver vasculature morphology ( J:163845 )

• the blood vessels in the livers of tamoxifen-treated mice exhibit larger luminal spaces than in wild-type mice

abnormal developmental vascular remodeling ( J:163845 )

• at E15.5, blood vessels in tamoxifen-treated mice are large and irregularly shaped compared to in wild-type mice

• brain vasculature in tamoxifen-treated mice is disorganized and interrupted by large spaces and cavities unlike in wild-type mice

• the blood vessels in the livers of tamoxifen-treated mice exhibit larger luminal spaces than in wild-type mice

dilated vasculature ( J:163845 )

• in tamoxifen-treated mice

hemorrhage ( J:163845 )

• at E15.5 in tamoxifen-treated mice

growth/size/body

decreased fetal size ( J:163845 )

• at E15.5 in tamoxifen-treated mice

liver/biliary system

abnormal liver vasculature morphology ( J:163845 )

• the blood vessels in the livers of tamoxifen-treated mice exhibit larger luminal spaces than in wild-type mice

nervous system

abnormal brain vasculature morphology ( J:163845 )

• brain vasculature in tamoxifen-treated mice is disorganized and interrupted by large spaces and cavities unlike in wild-type mice

integument

pallor ( J:163845 )

• at E15.5 in tamoxifen-treated mice