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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Eomestm1.1Bflu
targeted mutation 1.1, Binfeng Lu
MGI:4830338
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Eomestm1.1Bflu/Eomestm1.1Bflu
Tbx21tm1Glm/Tbx21tm1Glm
Tg(Cd4-cre)1Cwi/0 		involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL MGI:4830339
cn2
 		Eomestm1.1Bflu/Eomestm1.1Bflu
Tg(Cd4-cre)1Cwi/0 		involves: C57BL/6 * DBA/2 * SJL MGI:4830342


Genotype
MGI:4830339
cn1
Allelic
Composition		 Eomestm1.1Bflu/Eomestm1.1Bflu
Tbx21tm1Glm/Tbx21tm1Glm
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eomestm1.1Bflu mutation (1 available); any Eomes mutation (44 available)
Tbx21tm1Glm mutation (2 available); any Tbx21 mutation (39 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal leukocyte migration ( J:163822 )
• Th1 and Tc1 cells show a total lack of migration toward CXCL10
decreased memory T cell number ( J:163822 )
• CD44+ effector/memory T cells are reduced in both CD4+ and CD8+ T cells

immune system
abnormal leukocyte migration ( J:163822 )
• Th1 and Tc1 cells show a total lack of migration toward CXCL10
decreased memory T cell number ( J:163822 )
• CD44+ effector/memory T cells are reduced in both CD4+ and CD8+ T cells
decreased interferon-gamma secretion ( J:163822 )
• by CD8 cells cultured for 4 days under Th1 conditions
increased interleukin-17 secretion ( J:163822 )
• when CD8+ T cells are cultured in Th17-polarizing conditions 3 fold more IL17 producing cells are produced
increased interleukin-4 secretion ( J:163822 )
• when CD8+ T cells are cultured in Tc2-polarizing conditions 3 fold more IL4 producing cells are produced

neoplasm
increased tumor incidence ( J:163822 )
• 60% of mice vaccinated against B16 melenoma still grow tumors upon B16 injection

cellular
abnormal leukocyte migration ( J:163822 )
• Th1 and Tc1 cells show a total lack of migration toward CXCL10




Genotype
MGI:4830342
cn2
Allelic
Composition		 Eomestm1.1Bflu/Eomestm1.1Bflu
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6 * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eomestm1.1Bflu mutation (1 available); any Eomes mutation (44 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal leukocyte migration ( J:163822 )
• Th1 and Tc1 cells show a small decrease in migration to CXCL10
decreased memory T cell number ( J:163822 )
• CD44+ effector/memory T cells are reduced in both CD4+ and CD8+ T cells

immune system
abnormal leukocyte migration ( J:163822 )
• Th1 and Tc1 cells show a small decrease in migration to CXCL10
decreased memory T cell number ( J:163822 )
• CD44+ effector/memory T cells are reduced in both CD4+ and CD8+ T cells

neoplasm
increased tumor incidence ( J:163822 )
• 30% of mice allowed B16 melenoma tumor growth despite the vaccination against it

cellular
abnormal leukocyte migration ( J:163822 )
• Th1 and Tc1 cells show a small decrease in migration to CXCL10




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory