Phenotypes associated with this allele

• Allele Symbol: Usp18^ity9
• Allele Name: immunity to Typhimurium locus 9
• Allele ID: MGI:4830352
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Usp18^ity9/Usp18^ity9	involves: 129S1/SvImJ * C57BL/6	MGI:4830364
ht2	Usp18^ity9/Usp18^tm1Dez	involves: 129 * C57BL/6 * FVB/N	MGI:4830365

Genotype
MGI:4830364

hm1

• Allelic Composition: Usp18^ity9/Usp18^ity9
• Genetic Background: involves: 129S1/SvImJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:163843 )

• Salmonella-infected mice exhibit increased mortality compared with wild-type mice

• LPS-treated mice exhibit decreased survival compared with similarly treated wild-type mice

immune system

decreased leukocyte cell number ( J:163843 )

• moderate in Salmonella-infected mice

abnormal lymphocyte morphology ( J:163843 )

• polyI:C administration increases circulating lymphocytes and platelets reflecting an increased activation of the immune system compared to in wild-type mice

decreased circulating interferon-gamma level ( J:163843 )

• 2.5-fold lower in Salmonella-infected mice

increased circulating interleukin-6 level ( J:163843 )

• in Salmonella-infected mice

decreased interferon-gamma secretion ( J:163843 )

• in splenocytes from Salmonella-infected mice

• in splenocytes stimulated with IL2 or IFN-beta

increased interleukin-6 secretion ( J:163843 )

• splenocytes stimulated with LPS and zymosan

increased susceptibility to endotoxin shock ( J:163843 )

• LPS-treated mice exhibit decreased survival compared with similarly treated wild-type mice

• LPS and zymosan-stimulated splenocytes produce more IL6 than similarly treated wild-type cells

increased susceptibility to bacterial infection ( J:163843 )

• Salmonella-infected mice exhibit increased mortality, increased organ bacterial loads (36-fold higher in the spleen and 55-fold higher in the liver), a 2.5-fold lower IFN-gamma plasma level, mild anemia, moderate lymphopenia, marked thrombocytopenia, and increased circulating IL6 levels compared with wild-type mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:163843 )

• Salmonella-infected mice exhibit increased mortality compared with wild-type mice

• LPS-treated mice exhibit decreased survival compared with similarly treated wild-type mice

hematopoietic system

anemia ( J:163843 )

• mild in Salmonella-infected mice

thrombocytopenia ( J:163843 )

• marked in Salmonella-infected mice

decreased leukocyte cell number ( J:163843 )

• moderate in Salmonella-infected mice

abnormal lymphocyte morphology ( J:163843 )

• polyI:C administration increases circulating lymphocytes and platelets reflecting an increased activation of the immune system compared to in wild-type mice

homeostasis/metabolism

decreased circulating interferon-gamma level ( J:163843 )

• 2.5-fold lower in Salmonella-infected mice

increased circulating interleukin-6 level ( J:163843 )

• in Salmonella-infected mice

Genotype
MGI:4830365

ht2

• Allelic Composition: Usp18^ity9/Usp18^tm1Dez
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:163843 )

• Salmonella-infected mice exhibit increased mortality compared with wild-type mice

immune system

increased susceptibility to bacterial infection ( J:163843 )

• Salmonella-infected mice exhibit increased mortality and organ bacterial loads (6-fold higher in the spleen and 28-fold higher in the liver) compared with wild-type mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:163843 )

• Salmonella-infected mice exhibit increased mortality compared with wild-type mice