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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Htr2ctm1.1Eme
targeted mutation 1.1, Ronald Emeson
MGI:4830457
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Htr2ctm1.1Eme/Htr2ctm1.1Eme involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 MGI:4830464
ht2
 		Htr2ctm1.1Eme/Htr2c+ involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 MGI:4830463
ot3
 		Htr2ctm1.1Eme/Y involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 MGI:4830462


Genotype
MGI:4830464
hm1
Allelic
Composition		 Htr2ctm1.1Eme/Htr2ctm1.1Eme
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2ctm1.1Eme mutation (0 available); any Htr2c mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:163043 )
postnatal growth retardation ( J:163043 )




Genotype
MGI:4830463
ht2
Allelic
Composition		 Htr2ctm1.1Eme/Htr2c+
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2ctm1.1Eme mutation (0 available); any Htr2c mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:163043 )
• not as severe as in homozygotes or hemizygotes
postnatal growth retardation ( J:163043 )
• not as severe as in homozygotes or hemizygotes

behavior/neurological
decreased food intake ( J:163043 )
• gastric milk content is decreased compared to in wild-type mice




Genotype
MGI:4830462
ot3
Allelic
Composition		 Htr2ctm1.1Eme/Y
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2ctm1.1Eme mutation (0 available); any Htr2c mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality at weaning, incomplete penetrance ( J:163043 )
• Background Sensitivity: on a predominantly 129S6/SvEvTac background,10% to 20% of mice die between P21 and P24
postnatal lethality, incomplete penetrance ( J:163043 )
• Background Sensitivity: in a cross with a C57BL/6J male, 75% of mice die between P8 and P12 with none surviving beyond P15
• however, mortality can be minimized by feeding wet food paste on a predominantly 129S6/SvEvTac background

behavior/neurological
decreased food intake ( J:163043 )
• gastric milk content is decreased compared to in wild-type mice
increased food intake ( J:163043 )
• in adult mice when food consumption is corrected for weight
impaired coordination ( J:163043 )
• in weanlings (P2-P28) but not adults on a rotarod
decreased grip strength ( J:163043 )
• in weanlings (P2-P28) but not adults

growth/size/body
decreased body weight ( J:163043 )
• at P21 despite normal birth weight
decreased body length ( J:163043 )
postnatal growth retardation ( J:163043 )
• mice fail to thrive after birth
• however, mice exhibit normal growth rate after weaning

homeostasis/metabolism
increased energy expenditure ( J:163043 )
• total and resting energy adjusted for body weight are increased compared to in wild-type mice

muscle

pigmentation

integument

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Prader-Willi syndrome DOID:11983 OMIM:176270
 J:163043




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory