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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ppp1r1btm5.1Pggd
targeted mutation 5.1, Paul Greengard
MGI:4830458
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ppp1r1btm5.1Pggd/Ppp1r1btm5.1Pggd
Tg(Drd1-cre)EY262Gsat/0
Tg(Drd1-EGFP)X60Gsat/0 		involves: C57BL/6 * FVB/N * FVB/NTac MGI:4830459
cn2
 		Ppp1r1btm5.1Pggd/Ppp1r1btm5.1Pggd
Tg(Drd2-cre)ER44Gsat/0
Tg(Drd2-EGFP)S118Gsat/0 		involves: C57BL/6 * FVB/N * FVB/NTac MGI:4830460


Genotype
MGI:4830459
cn1
Allelic
Composition		 Ppp1r1btm5.1Pggd/Ppp1r1btm5.1Pggd
Tg(Drd1-cre)EY262Gsat/0
Tg(Drd1-EGFP)X60Gsat/0
Genetic
Background		 involves: C57BL/6 * FVB/N * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r1btm5.1Pggd mutation (0 available); any Ppp1r1b mutation (18 available)
Tg(Drd1-cre)EY262Gsat mutation (2 available)
Tg(Drd1-EGFP)X60Gsat mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
reduced long-term potentiation ( J:163700 )
• loss of expression in striatopallidal and striatonigral neurons results in a reduced LTP at the corticostriatal synapses

behavior/neurological
impaired behavioral response to xenobiotic ( J:163700 )
• haloperidol-induced catalepsy is reduced
• L-DOPA-induced dyskinesia. is absent
decreased locomotor activity ( J:163700 )
• in an open-field test




Genotype
MGI:4830460
cn2
Allelic
Composition		 Ppp1r1btm5.1Pggd/Ppp1r1btm5.1Pggd
Tg(Drd2-cre)ER44Gsat/0
Tg(Drd2-EGFP)S118Gsat/0
Genetic
Background		 involves: C57BL/6 * FVB/N * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r1btm5.1Pggd mutation (0 available); any Ppp1r1b mutation (18 available)
Tg(Drd2-cre)ER44Gsat mutation (2 available)
Tg(Drd2-EGFP)S118Gsat mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
reduced long-term potentiation ( J:163700 )
• loss of expression in striatopallidal and striatonigral neurons results in a reduced LTP at the corticostriatal synapses

behavior/neurological
impaired behavioral response to xenobiotic ( J:163700 )
• haloperidol-induced catalepsy is strongly reduced
hyperactivity ( J:163700 )
• in an open-field test




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory