Phenotypes associated with this allele

• Allele Symbol: Cyp1a1^tm4.1Dwn
• Allele Name: targeted mutation 4.1, Daniel W Nebert
• Allele ID: MGI:4830524
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cyp1a1^tm4.1Dwn/Cyp1a1^tm4.1Dwn	B6.129X1-Cyp1a1^tm4.1Dwn	MGI:4830530

Genotype
MGI:4830530

hm1

• Allelic Composition: Cyp1a1^tm4.1Dwn/Cyp1a1^tm4.1Dwn
• Genetic Background: B6.129X1-Cyp1a1^tm4.1Dwn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating alanine transaminase level ( J:163973 )

• in benzo[a]pyrene (BaP)-treated mice

increased circulating aspartate transaminase level ( J:163973 )

• in benzo[a]pyrene (BaP)-treated mice

increased physiological sensitivity to xenobiotic ( J:163973 )

• benzo[a]pyrene (BaP)-treated mice exhibit moderate toxicity (weight loss, decreased spleen and thymus weight, increased liver weight, increased serum alanine and aspartate transaminase levels, decreased hematocrit and hemoglobin, increased methemoglobin, increased neutrophils, and decreased lymphocytes) compared with similarly treated wild-type mice

• BaP-toxicity is not as severe as in similarly treated Cyp1a1^tm1.1Dwn homozygotes

abnormal xenobiotic pharmacokinetics ( J:163973 )

• benzo[a]pyrene (BaP)-treated mice exhibit an 25-fold increase in BaP serum levels compared to wild-type mice

hematopoietic system

decreased thymus weight ( J:163973 )

• in benzo[a]pyrene (BaP)-treated mice

decreased hematocrit ( J:163973 )

• in benzo[a]pyrene (BaP)-treated mice

abnormal hemoglobin content ( J:163973 )

• benzo[a]pyrene (BaP)-treated mice exhibit an increase in methemoglobin compared with similarly treated wild-type mice

increased hemoglobin content ( J:163973 )

• in benzo[a]pyrene (BaP)-treated mice

increased neutrophil cell number ( J:163973 )

• in benzo[a]pyrene (BaP)-treated mice

decreased lymphocyte cell number ( J:163973 )

• in benzo[a]pyrene (BaP)-treated mice

decreased spleen weight ( J:163973 )

• in benzo[a]pyrene (BaP)-treated mice

liver/biliary system

increased liver weight ( J:163973 )

• in benzo[a]pyrene (BaP)-treated mice

growth/size/body

increased susceptibility to weight loss ( J:163973 )

• in benzo[a]pyrene (BaP)-treated mice

increased liver weight ( J:163973 )

• in benzo[a]pyrene (BaP)-treated mice

immune system

decreased thymus weight ( J:163973 )

• in benzo[a]pyrene (BaP)-treated mice

increased neutrophil cell number ( J:163973 )

• in benzo[a]pyrene (BaP)-treated mice

decreased lymphocyte cell number ( J:163973 )

• in benzo[a]pyrene (BaP)-treated mice

decreased spleen weight ( J:163973 )

• in benzo[a]pyrene (BaP)-treated mice

endocrine/exocrine glands

decreased thymus weight ( J:163973 )

• in benzo[a]pyrene (BaP)-treated mice