Analysis Tools
mortality/aging
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• Background Sensitivity: on a mixed 129S2/SvPas and C57BL/6 background, most mice die between P1 and P2 with few surviving to P21
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• on a congenic C57BL/6 background, no viable mice are observed postnatally
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cardiovascular system
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• at E18.5, mice exhibit abnormal myocardium structural organization compared to in wild-type mice
• at E18.5, mice exhibit reduced myocyte nuclei per unit area of tissue compared to in wild-type mice
• at E18.5, myocyte size is increased compared to in wild-type mice
• at E18.5, cardiomyocytes of the myocardial layer contain vacuoles and less well-developed striations compared to in wild-type mice
• at E18.5, mice exhibit myofibril degeneration and sarcomere fragmentation unlike in wild-type mice
• however, rates of cardiomyocyte apoptosis are normal
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• at E18.5, the number of maturing cardiomyocytes per mm3 of tissue is reduced by 17%
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• at E18.5, cardiomyocytes of the myocardial layer contain vacuoles
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• at E18.5, myocyte volume is increased by 20% compared to in wild-type mice
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• subepicardial vessels are dilated compared to in wild-type mice
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• at E18.5
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• the epicardial through myocardial layers of the left ventricular free wall are thinner compared to in wild-type mice
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• E16.5 and dramatic at E18.5
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• at E18.5
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• at E18.5
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• at E18.5
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• at E18.5, mice exhibit reduced left ventricular fractional shortening and ejection fraction compared with wild-type mice
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respiratory system
small lung
(
J:163968
)
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• due to compression by the enlarged heart, mice exhibit reduced lung size compared with wild-type mice
• however, mice exhibit normal lung weight and inflation
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muscle
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• at E18.5, mice exhibit reduced left ventricular fractional shortening and ejection fraction compared with wild-type mice
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growth/size/body
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• at E18.5
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