Phenotypes associated with this allele

• Allele Symbol: Slc47a1^tm1Kinu
• Allele Name: targeted mutation 1, Ken-ichi Inui
• Allele ID: MGI:4830581
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc47a1^tm1Kinu/Slc47a1^tm1Kinu	C57BL/6-Slc47a1^tm1Kinu	MGI:4830582

Genotype
MGI:4830582

hm1

• Allelic Composition: Slc47a1^tm1Kinu/Slc47a1^tm1Kinu
• Genetic Background: C57BL/6-Slc47a1^tm1Kinu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating creatinine level ( J:163959 )

increased blood urea nitrogen level ( J:163959 )

abnormal xenobiotic pharmacokinetics ( J:163959 )

• in metoformin treated mice, plasma levels of metformin are increased (2-fold increased in the area under the blood concentration-time curve for 60 min) while urine levels are decreased compared to in similarly treated wild-type mice

• kidneys and livers of metformin-treated mice exhibit increased concentrations and decreased clearance of metformin compared with similarly treated wild-type mice