Phenotypes associated with this allele

• Allele Symbol: Anpep^tm1.1Lsha
• Allele Name: targeted mutation 1.1, Linda H Shapiro
• Allele ID: MGI:4830680
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Anpep^tm1.1Lsha/Anpep^tm1.1Lsha	B6.Cg-Anpep^tm1.1Lsha	MGI:4830681

Genotype
MGI:4830681

hm1

• Allelic Composition: Anpep^tm1.1Lsha/Anpep^tm1.1Lsha
• Genetic Background: B6.Cg-Anpep^tm1.1Lsha

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:163945 )

N • mice exhibit normal acute inflammatory processes, experimental colitis, and collagen antibody-induced arthritis

increased CD4-positive, alpha-beta T cell number ( J:163945 )

• mice exhibit an increase in thymic CD4+ cells compared with wild-type mice

• however, CD4 populations in peripheral organs is normal

abnormal macrophage physiology ( J:163945 )

• macrophage adhesion to endothelial cell monolayers is slightly decreased and is not stimulated by cross-linking with anti-CD13 (Anpep) antibodies unlike similarly treated wild-type cells

hematopoietic system

increased CD4-positive, alpha-beta T cell number ( J:163945 )

• mice exhibit an increase in thymic CD4+ cells compared with wild-type mice

• however, CD4 populations in peripheral organs is normal

abnormal macrophage physiology ( J:163945 )

• macrophage adhesion to endothelial cell monolayers is slightly decreased and is not stimulated by cross-linking with anti-CD13 (Anpep) antibodies unlike similarly treated wild-type cells