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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Comttm1Mkae
targeted mutation 1, Mikko Kaenmaki
MGI:4830700
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Comttm1Mkae/Comttm1Mkae involves: C57BL/6J MGI:4830778


Genotype
MGI:4830778
hm1
Allelic
Composition		 Comttm1Mkae/Comttm1Mkae
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Comttm1Mkae mutation (0 available); any Comt mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal xenobiotic pharmacokinetics ( J:164057 )
• an increase in liver L-DOPA levels after oral administration of L-DOPA, compared to wild-type
• the levels of 3-O-methyldopa are significantly decreased after oral administration of L-DOPA compared to wild-type




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory