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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptpn12tm1Vei
targeted mutation 1, Andre Veillette
MGI:4830749
Summary 2 genotypes


Genotype
MGI:4830771
cn1
Allelic
Composition		 Ptpn12tm1Vei/Ptpn12tm1Vei
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 B6.Cg-Tg(Cd4-cre)1Cwi Ptpn12tm1Vei
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn12tm1Vei mutation (0 available); any Ptpn12 mutation (52 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell physiology ( J:163910 )
• ability to form large T cell aggregates after antigen re-stimulation is severely compromised
decreased T cell proliferation ( J:163910 )
• thymidine incorporation by CD4+ T cells after antigen re-stimulation is reduced by 50%
• decreased cell division
• defect in thymidine incorporation is rescued by addition of IL-2
abnormal cytokine secretion ( J:163910 )
• cytokine production is reduced to 10-20% of control levels after antigen re-stimulation

hematopoietic system
abnormal T cell physiology ( J:163910 )
• ability to form large T cell aggregates after antigen re-stimulation is severely compromised
decreased T cell proliferation ( J:163910 )
• thymidine incorporation by CD4+ T cells after antigen re-stimulation is reduced by 50%
• decreased cell division
• defect in thymidine incorporation is rescued by addition of IL-2

cellular
decreased T cell proliferation ( J:163910 )
• thymidine incorporation by CD4+ T cells after antigen re-stimulation is reduced by 50%
• decreased cell division
• defect in thymidine incorporation is rescued by addition of IL-2




Genotype
MGI:4830774
cn2
Allelic
Composition		 Ptpn12tm1Vei/Ptpn12tm1Vei
Tg(Lck-cre)1Cwi/0
Genetic
Background		 B6.Cg-Ptpn12tm1Vei Tg(Lck-cre)1Cwi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn12tm1Vei mutation (0 available); any Ptpn12 mutation (52 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:163910 )
• much less susceptible to experimental autoimmune encephalitis induced by antibodies to Mog
• primary immune response to Mog is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory