Analysis Tools|
Allele Symbol Allele Name Allele ID |
Ppcd1 posterior polymorphous corneal dystrophy 1 MGI:4830871 |
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| Summary |
8 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Eye abnormalities in Ppcd1/0 mice
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• at P3, the cells in the iridocorneal angle are more densely packed than in wild-type mice
• at P5, the iridocorneal angle is occluded compared to in wild-type mice
• however, the irridocorneal angle is normal immediately after birth
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• the trabecular meshwork of the eye is occluded by multilayered, stratified endothelial cells that exhibit an epithelial morphology, are visible in the iridocorneal angle and on the posterior surface of the cornea and anterior surface of the iris, and migrate onto the central cornea unlike in wild-type mice
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• mice exhibit inappropriate cytokeratin AE1/AE3 immunoreactivity in the corneal endothelium and iridocorneal angle, extending onto the anterior surface of the iris and posterior surface of the cornea unlike in wild-type mice
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• in some mice
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• mice exhibit lens subluxation and proliferation of cells over the surface of the lens unlike wild-type mice
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• eye diameter is increased compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Background Sensitivity: 38% of mice exhibit enlarged eyes in an F1 cross to C57BL/6 compared with 44% of mice in F1 cross to FVB/N
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Background Sensitivity: 44% of mice exhibit enlarged eyes in an F1 cross to FVB/N compared with 38% of mice in an F1 cross to C57BL/6
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Eye abnormalities in Ppcd1/0 mice
| N |
• mice backcrossed to C57BL/6 for 3 generations do not exhibit the Corneal Dystrophy, Posterior Polymorphous, 1 (PPCD1) phenotype
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• mice exhibit corneal haze, neovascularization, ulcers, and scarring unlike wild-type mice
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• the anterior chamber is deep and enlarged compared to in wild-type mice
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• mice exhibit lens subluxation unlike wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no mice are present when survival is scored at weaning
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no mice are present when survival is scored at weaning
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 50% of mice die prior to birth
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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