All Phenotypes Mecp2<tm1.1Irsf> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Mecp2^tm1.1Irsf/Mecp2⁺	involves: 129S2/SvPas * C57BL/6	MGI:5751716
ht2	Mecp2^tm1.1Irsf/Mecp2⁺	involves: 129S/Sv * C57BL/6	MGI:5429579
ot3	Mecp2^tm1.1Irsf/Y	involves: 129S2/SvPas * C57BL/6	MGI:5751707
ot4	Mecp2^tm1.1Irsf/Y	involves: 129S/Sv * C57BL/6	MGI:5429580

Allelic Composition	Mecp2^tm1.1Irsf/Mecp2⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1.1Irsf mutation (1 available); any Mecp2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired coordination ( J:220859 )

• mice show increased footslips in the parallel rod walking task and impaired ability to learn the accelerating rotating rod walking task at 17 weeks of age

• however, no difference is seen in the motor coordination task of dowel hang time and mice exhibit normal behaviors in the elevated plus maze

tonic-clonic seizures ( J:220859 )

• two mice show tonic-clonic seizures followed by death after handling

respiratory system

increased pulmonary respiratory rate ( J:220859 )

• 8 month old mice exhibit increased breathing rate when exposed to a hypoxic gas challenge

cardiovascular system

increased heart weight ( J:220859 )

• increase in heart weight by 8 months

prolonged QT interval ( J:220859 )

• 8 month old mice show increased corrected QT interval time

growth/size/body

increased heart weight ( J:220859 )

• increase in heart weight by 8 months

increased body weight ( J:220859 )

• mice become overweight by 10 weeks of age

increased liver weight ( J:220859 )

• increase in liver weight by 8 months of age

liver/biliary system

increased liver weight ( J:220859 )

• increase in liver weight by 8 months of age

mortality/aging

premature death ( J:220859 )

• median survival of 224 days

nervous system

tonic-clonic seizures ( J:220859 )

• two mice show tonic-clonic seizures followed by death after handling

decreased brain weight ( J:220859 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:220859

Allelic Composition	Mecp2^tm1.1Irsf/Mecp2⁺
Genetic Background	involves: 129S/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1.1Irsf mutation (1 available); any Mecp2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:185639 )

• moderate obesity seen in some female mice

behavior/neurological

lethargy ( J:185639 )

• in some female mice

impaired coordination ( J:185639 )

• in some female mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired contextual conditioning behavior ( J:220859 )

• mice exhibit impaired contextual long-term memory at 6 weeks of age

decreased anxiety-related response ( J:220859 )

• mice make more entries into, travel greater distances, and spend increased time in the open arm of the elevated plus maze at 6 weeks of age, indicating decreased anxiety

impaired coordination ( J:220859 )

• mice exhibit increased footslips when walking on an array of parallel bars, decreased ability to remain suspended on a 1/4 inch diameter dowel, and impaired ability to learn the accelerating rotating rod walking task at 6 weeks of age

cardiovascular system

irregular heartbeat ( J:220859 )

• mice over 8 weeks of age show increased incidence of arrhythmia

prolonged QT interval ( J:220859 )

• mice over 8 weeks of age show increased corrected QT interval time

growth/size/body

decreased body weight ( J:220859 )

• mice are underweight at weaning but recover to wild-type body weight by 6 weeks of age

mortality/aging

premature death ( J:220859 )

• median survival of 61 days

nervous system

decreased brain weight ( J:220859 )

abnormal excitatory postsynaptic potential ( J:220859 )

• mice exhibit decreased evoked field excitatory post-synaptic potential (fEPSP) slope in CA1 region of the hippocampus

reduced long-term potentiation ( J:220859 )

• mice exhibit decreased evoked field excitatory post-synaptic potential (fEPSP) slope in CA1 region of the hippocampus, indicating impaired long-term potentiation

respiratory system

increased pulmonary respiratory rate ( J:220859 )

• 6-8 week old mice have increased breathing rate at baseline and when exposed to a hypoxic gas challenge

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:220859

Allelic Composition	Mecp2^tm1.1Irsf/Y
Genetic Background	involves: 129S/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1.1Irsf mutation (1 available); any Mecp2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

limb grasping ( J:185639 )

• hind limb clasping

impaired coordination ( J:185639 )

abnormal gait ( J:185639 )

growth/size/body

increased body weight ( J:185639 )

• exhibit excessive weight gain

• up to 10g heavier than controls at 3 weeks of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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