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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mecp2tm1.1Irsf
targeted mutation 1.1, International Rett Syndrome Foundation
MGI:4830980
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Mecp2tm1.1Irsf/Mecp2+ involves: 129S2/SvPas * C57BL/6 MGI:5751716
ht2
Mecp2tm1.1Irsf/Mecp2+ involves: 129S/Sv * C57BL/6 MGI:5429579
ot3
Mecp2tm1.1Irsf/Y involves: 129S2/SvPas * C57BL/6 MGI:5751707
ot4
Mecp2tm1.1Irsf/Y involves: 129S/Sv * C57BL/6 MGI:5429580


Genotype
MGI:5751716
ht1
Allelic
Composition
Mecp2tm1.1Irsf/Mecp2+
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1.1Irsf mutation (1 available); any Mecp2 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice show increased footslips in the parallel rod walking task and impaired ability to learn the accelerating rotating rod walking task at 17 weeks of age
• however, no difference is seen in the motor coordination task of dowel hang time and mice exhibit normal behaviors in the elevated plus maze
• two mice show tonic-clonic seizures followed by death after handling

respiratory system
• 8 month old mice exhibit increased breathing rate when exposed to a hypoxic gas challenge

cardiovascular system
• increase in heart weight by 8 months
• 8 month old mice show increased corrected QT interval time

growth/size/body
• increase in heart weight by 8 months
• mice become overweight by 10 weeks of age
• increase in liver weight by 8 months of age

liver/biliary system
• increase in liver weight by 8 months of age

mortality/aging
• median survival of 224 days

nervous system
• two mice show tonic-clonic seizures followed by death after handling

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Rett syndrome DOID:1206 OMIM:312750
OMIM:613454
J:220859




Genotype
MGI:5429579
ht2
Allelic
Composition
Mecp2tm1.1Irsf/Mecp2+
Genetic
Background
involves: 129S/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1.1Irsf mutation (1 available); any Mecp2 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• moderate obesity seen in some female mice

behavior/neurological
• in some female mice
• in some female mice




Genotype
MGI:5751707
ot3
Allelic
Composition
Mecp2tm1.1Irsf/Y
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1.1Irsf mutation (1 available); any Mecp2 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit impaired contextual long-term memory at 6 weeks of age
• mice make more entries into, travel greater distances, and spend increased time in the open arm of the elevated plus maze at 6 weeks of age, indicating decreased anxiety
• mice exhibit increased footslips when walking on an array of parallel bars, decreased ability to remain suspended on a 1/4 inch diameter dowel, and impaired ability to learn the accelerating rotating rod walking task at 6 weeks of age

cardiovascular system
• mice over 8 weeks of age show increased incidence of arrhythmia
• mice over 8 weeks of age show increased corrected QT interval time

growth/size/body
• mice are underweight at weaning but recover to wild-type body weight by 6 weeks of age

mortality/aging
• median survival of 61 days

nervous system
• mice exhibit decreased evoked field excitatory post-synaptic potential (fEPSP) slope in CA1 region of the hippocampus
• mice exhibit decreased evoked field excitatory post-synaptic potential (fEPSP) slope in CA1 region of the hippocampus, indicating impaired long-term potentiation

respiratory system
• 6-8 week old mice have increased breathing rate at baseline and when exposed to a hypoxic gas challenge

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Rett syndrome DOID:1206 OMIM:312750
OMIM:613454
J:220859




Genotype
MGI:5429580
ot4
Allelic
Composition
Mecp2tm1.1Irsf/Y
Genetic
Background
involves: 129S/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1.1Irsf mutation (1 available); any Mecp2 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• hind limb clasping

growth/size/body
• exhibit excessive weight gain
• up to 10g heavier than controls at 3 weeks of age





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory