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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(NOTCH3)Sat
targeted mutation 1, Spyros Artavanis-Tsakonas
MGI:4830990
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Gt(ROSA)26Sortm1(NOTCH3)Sat/Gt(ROSA)26Sor+ involves: 129S6/SvEvTac * C57BL/6 MGI:4830997
cn2
 		Gt(ROSA)26Sortm1(NOTCH3)Sat/Gt(ROSA)26Sor+
Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg
Tg(Tagln-cre)1Her/0 		involves: 129 * C57BL/6 * SJL MGI:5007818
cn3
 		Gt(ROSA)26Sortm1(NOTCH3)Sat/Gt(ROSA)26Sor+
Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg
Tg(Tagln-cre)1Her/0 		involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL MGI:4830996


Genotype
MGI:4830997
ht1
Allelic
Composition		 Gt(ROSA)26Sortm1(NOTCH3)Sat/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(NOTCH3)Sat mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:133358 )
• mice are viable and fertile and displayed no gross abnormalities




Genotype
MGI:5007818
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(NOTCH3)Sat/Gt(ROSA)26Sor+
Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg
Tg(Tagln-cre)1Her/0
Genetic
Background		 involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(NOTCH3)Sat mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Notch3Gt(PST033)Byg mutation (0 available); any Notch3 mutation (94 available)
Tg(Tagln-cre)1Her mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:171887 )
N
• increased susceptibility to ischemic injury seen in Notch3 null mice is rescued by expression of the human NOTCH3




Genotype
MGI:4830996
cn3
Allelic
Composition		 Gt(ROSA)26Sortm1(NOTCH3)Sat/Gt(ROSA)26Sor+
Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg
Tg(Tagln-cre)1Her/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(NOTCH3)Sat mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Notch3Gt(PST033)Byg mutation (0 available); any Notch3 mutation (94 available)
Tg(Tagln-cre)1Her mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased cerebral infarct size ( J:133358 )
• following filament middle cerebral artery occlusion, mice exhibit reduced infarct volume compared with similarly treated Notch3Gt(PST033)Byg homozygotes

nervous system
decreased cerebral infarct size ( J:133358 )
• following filament middle cerebral artery occlusion, mice exhibit reduced infarct volume compared with similarly treated Notch3Gt(PST033)Byg homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory