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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sec61a1m1Gek
mutation 1, Nicholas Gekakis
MGI:4830998
Summary 3 genotypes


Genotype
MGI:4831012
hm1
Allelic
Composition		 Sec61a1m1Gek/Sec61a1m1Gek
Genetic
Background		 C57BL/6J-Sec61a1m1Gek
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sec61a1m1Gek mutation (1 available); any Sec61a1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating cholesterol level ( J:164159 )
• in mice fed a high fat diet
increased circulating triglyceride level ( J:164159 )
• in mice fed a high fat diet
hyperglycemia ( J:164159 )
• in male mice fed chow or a high fat diet
• in female mice fed a high fat diet
increased circulating glucagon level ( J:164159 )
• mice fed a high fat diet exhibit a trend towards increased plasma glucagon compared with similarly treated wild-type mice that does not reach statistical significance
decreased circulating insulin level ( J:164159 )
• in male mice fed chow or a high fat diet
• in female mice fed a high fat diet
impaired glucose tolerance ( J:164159 )
• in mice fed chow or a high fat diet

endocrine/exocrine glands
increased pancreatic alpha cell number ( J:164159 )
• in mice fed a high fat diet
abnormal pancreatic beta cell morphology ( J:164159 )
• in mice fed chow or a high fat diet, beta cells exhibit distended endoplasmic reticulum unlike wild-type cells
decreased pancreatic beta cell number ( J:164159 )
• 3 months after mice are fed chow or a high fat diet
abnormal pancreatic delta cell morphology ( J:164159 )
• delta cells in mice fed a high fat diet are mislocalized to the interior of the islet as opposed to the peripheral position as in wild-type mice
increased pancreatic delta cell number ( J:164159 )
• 3 months after high fat diet feeding
abnormal pancreatic beta cell physiology ( J:164159 )
• in mice fed a high fat diet, beta cells exhibit increased expression of endoplasmic reticulum stress markers compared to in wild-type cells
increased pancreatic beta cell apoptosis ( J:164159 )
• in mice fed a high fat diet

liver/biliary system
increased hepatocyte apoptosis ( J:164159 )
• at 8 and 12 weeks
enlarged liver ( J:164159 )
• in mice fed a high fat diet
hepatic steatosis ( J:164159 )
• in mice fed a high fat diet
liver cirrhosis ( J:164159 )
• in older mice when fed a high fat diet
pale liver ( J:164159 )
• in mice fed a high fat diet

growth/size/body
decreased lean body mass ( J:164159 )
• in male mice fed chow or a high fat diet
• in female mice fed a high fat diet
decreased body size ( J:164159 )
• in male mice fed chow or a high fat diet
• in female mice fed a high fat diet
enlarged liver ( J:164159 )
• in mice fed a high fat diet

adipose tissue
decreased total body fat amount ( J:164159 )
• in male mice fed chow or a high fat diet
• in female mice fed a high fat diet

muscle
decreased skeletal muscle mass ( J:164159 )
• in mice fed a high fat diet

cellular
increased pancreatic beta cell apoptosis ( J:164159 )
• in mice fed a high fat diet
increased hepatocyte apoptosis ( J:164159 )
• at 8 and 12 weeks




Genotype
MGI:4831011
ht2
Allelic
Composition		 Sec61a1m1Gek/Sec61a1+
Genetic
Background		 C57BL/6J-Sec61a1m1Gek
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sec61a1m1Gek mutation (1 available); any Sec61a1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
hyperglycemia ( J:164159 )
• when fed a high fat diet although not as severe as in homozygotes
decreased circulating insulin level ( J:164159 )
• when fed a high fat diet although not as severe as in homozygotes




Genotype
MGI:4831013
cx3
Allelic
Composition		 Sec61a1m1Gek/Sec61a1m1Gek
Tg(Ins2-Sec61a1)#Gek/0
Genetic
Background		 C57BL/6-Sec61a1m1Gek Tg(Ins2-Sec61a1)#Gek
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sec61a1m1Gek mutation (1 available); any Sec61a1 mutation (16 available)
Tg(Ins2-Sec61a1)#Gek mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:164159 )
N
• mice fed a high fat diet exhibit normal glucose and insulin homeostasis

liver/biliary system
enlarged liver ( J:164159 )
• in mice fed a high fat diet that is not as severe as in similarly treated Sec61a1m1Gek homozygotes
hepatic steatosis ( J:164159 )
• in mice fed a high fat diet
liver cirrhosis ( J:164159 )
• in older mice when fed a high fat diet

endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:164159 )
N
• mice fed a high fat diet exhibit normal beta cell survival
abnormal pancreatic beta cell morphology ( J:164159 )
• endoplasmic reticulum distension observed in single homozygotes is almost completely rescued

growth/size/body
decreased lean body mass ( J:164159 )
• in mice fed a high fat diet that is not as severe as in similarly treated Sec61a1m1Gek homozygotes
decreased body size ( J:164159 )
• in mice fed a high fat diet that is not as severe as in similarly treated Sec61a1m1Gek homozygotes
enlarged liver ( J:164159 )
• in mice fed a high fat diet that is not as severe as in similarly treated Sec61a1m1Gek homozygotes

adipose tissue
decreased total body fat amount ( J:164159 )
• in mice fed a high fat diet that is not as severe as in similarly treated Sec61a1m1Gek homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/24/2024
MGI 6.24 		The Jackson Laboratory