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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnfaip3tm2Ama
targeted mutation 2, Averil Ma
MGI:4831001
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tnfaip3tm2Ama/Tnfaip3tm2Ama
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:4831002
cn2
 		Cd19tm1(cre)Cgn/Cd19+
Tnfaip3tm2Ama/Tnfaip3+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:4831003


Genotype
MGI:4831002
cn1
Allelic
Composition		 Tnfaip3tm2Ama/Tnfaip3tm2Ama
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Tnfaip3tm2Ama mutation (0 available); any Tnfaip3 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell apoptosis ( J:163917 )
• B cells are resistant to Fas-mediated programmed cell death compared to controls
increased T cell number ( J:163917 )
• moderate expansion of T cells
abnormal B cell morphology ( J:163917 )
• increase in the number and size of anti-DNA producing B cells
decreased B cell number ( J:163917 )
• small decrease in the percentage of IgM+B cells in the bone marrow, reflecting a reduction in mature or recirculating B cells
increased B cell number ( J:163917 )
• moderate increase in B cells
increased plasma cell number ( J:163917 )
• increase in percentage of splenic plasma cells
abnormal B-1a B cell morphology ( J:163917 )
• percentage of B-1a cells in the peritoneal cavity is lower than in controls but the absolute numbers are not different
abnormal B cell activation ( J:163917 )
• spontaneous B cell activation becomes apparent at 6 months of age
increased B cell proliferation ( J:163917 )
• B cells are hyperresponsive to multiple stimuli
• B cells exhibit exaggerated NF-kappaB responses to CD40-induced signals
increased immunoglobulin level ( J:163917 )
• increase in glomerular immunoglobulin deposits
increased IgG level ( J:163917 )
• modest increase in IgGs
increased interleukin-6 secretion ( J:163917 )
• increase in IL-6 production by B cells after treatment with LPS and CpG
increased susceptibility to autoimmune disorder ( J:163917 )
• CpG treatment enhances production of IgG dsDNA antibodies in serum as well as deposition of IgG in renal glomeruli, indicating development of autoimmune disease
• IgM deposits are seen in the kidneys
increased autoantibody level ( J:163917 )
• mice develop autoimmunity; antibodies to over 46 self-antigens are detected, including antibodies to nuclear antigens

hematopoietic system
decreased B cell apoptosis ( J:163917 )
• B cells are resistant to Fas-mediated programmed cell death compared to controls
increased T cell number ( J:163917 )
• moderate expansion of T cells
abnormal B cell morphology ( J:163917 )
• increase in the number and size of anti-DNA producing B cells
decreased B cell number ( J:163917 )
• small decrease in the percentage of IgM+B cells in the bone marrow, reflecting a reduction in mature or recirculating B cells
increased B cell number ( J:163917 )
• moderate increase in B cells
increased plasma cell number ( J:163917 )
• increase in percentage of splenic plasma cells
abnormal B-1a B cell morphology ( J:163917 )
• percentage of B-1a cells in the peritoneal cavity is lower than in controls but the absolute numbers are not different
abnormal B cell activation ( J:163917 )
• spontaneous B cell activation becomes apparent at 6 months of age
increased B cell proliferation ( J:163917 )
• B cells are hyperresponsive to multiple stimuli
• B cells exhibit exaggerated NF-kappaB responses to CD40-induced signals
increased immunoglobulin level ( J:163917 )
• increase in glomerular immunoglobulin deposits
increased IgG level ( J:163917 )
• modest increase in IgGs

cellular
decreased B cell apoptosis ( J:163917 )
• B cells are resistant to Fas-mediated programmed cell death compared to controls
increased B cell proliferation ( J:163917 )
• B cells are hyperresponsive to multiple stimuli
• B cells exhibit exaggerated NF-kappaB responses to CD40-induced signals




Genotype
MGI:4831003
cn2
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Tnfaip3tm2Ama/Tnfaip3+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Tnfaip3tm2Ama mutation (0 available); any Tnfaip3 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell apoptosis ( J:163917 )
• B cells are resistant to Fas-mediated programmed cell death compared to controls
increased plasma cell number ( J:163917 )
• increase in percentage of splenic plasma cells
increased immunoglobulin level ( J:163917 )
• IgM and IgG deposits are seen in the kidneys
increased susceptibility to autoimmune disorder ( J:163917 )
• CpG treatment enhances production of IgG dsDNA antibodies in serum as well as deposition of IgG in renal glomeruli, indicating development of autoimmune disease

hematopoietic system
decreased B cell apoptosis ( J:163917 )
• B cells are resistant to Fas-mediated programmed cell death compared to controls
increased plasma cell number ( J:163917 )
• increase in percentage of splenic plasma cells
increased immunoglobulin level ( J:163917 )
• IgM and IgG deposits are seen in the kidneys

cellular
decreased B cell apoptosis ( J:163917 )
• B cells are resistant to Fas-mediated programmed cell death compared to controls




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory