All Phenotypes Tg(Thy1-YFP)#Jrs MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Thy1-YFP)#Jrs
transgene insertion, Joshua R Sanes
MGI:4831125

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Cdkl5^tm1.2Cogr/Y Tg(Thy1-YFP)#Jrs/0	involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA	MGI:5574075
cx2	Cdkl5^tm1.2Cogr/Cdkl5^tm1.2Cogr Tg(Thy1-YFP)#Jrs/0	involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA	MGI:5574076
cx3	Cdkl5^tm1.2Cogr/Cdkl5⁺ Tg(Thy1-YFP)#Jrs/0	involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA	MGI:5574077

Allelic Composition	Cdkl5^tm1.2Cogr/Y Tg(Thy1-YFP)#Jrs/0
Genetic Background	involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkl5^tm1.2Cogr mutation (2 available); any Cdkl5 mutation (20 available)
Tg(Thy1-YFP)#Jrs mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal hippocampus layer morphology ( J:209635 )

• reduced thickness

thin hippocampus molecular cell layer ( J:209635 )

thin hippocampus stratum oriens ( J:209635 )

thin cerebral cortex ( J:209635 )

abnormal dendrite morphology ( J:209635 )

• reduced total length of apical dendritic arbors of cortical and hippocampal pyramidal neurons

• reduced branching of pyramidal neuron dendrites

Allelic Composition	Cdkl5^tm1.2Cogr/Cdkl5^tm1.2Cogr Tg(Thy1-YFP)#Jrs/0
Genetic Background	involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkl5^tm1.2Cogr mutation (2 available); any Cdkl5 mutation (20 available)
Tg(Thy1-YFP)#Jrs mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal hippocampus layer morphology ( J:209635 )

• reduced thickness

thin hippocampus molecular cell layer ( J:209635 )

thin hippocampus stratum oriens ( J:209635 )

thin cerebral cortex ( J:209635 )

abnormal dendrite morphology ( J:209635 )

• reduced total length of apical dendritic arbors of cortical and hippocampal pyramidal neurons

• reduced branching of pyramidal neuron dendrites

Allelic Composition	Cdkl5^tm1.2Cogr/Cdkl5⁺ Tg(Thy1-YFP)#Jrs/0
Genetic Background	involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkl5^tm1.2Cogr mutation (2 available); any Cdkl5 mutation (20 available)
Tg(Thy1-YFP)#Jrs mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

thin cerebral cortex ( J:209635 )

• intermediate

abnormal dendrite morphology ( J:209635 )

• intermediate reduction in total length of apical dendritic arbors of cortical and hippocampal pyramidal neurons with bimodal distribution

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