Phenotypes associated with this allele

• Allele Symbol: Cend1^tm1.1Rmat
• Allele Name: targeted mutation 1.1, Rebecca Matsas
• Allele ID: MGI:4831137
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cend1^tm1.1Rmat/Cend1^tm1.1Rmat	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6	MGI:4831138

Genotype
MGI:4831138

hm1

• Allelic Composition: Cend1^tm1.1Rmat/Cend1^tm1.1Rmat
• Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal cerebellar granule cell migration ( J:164148 )

• a delay in migration is detected 72 - 96 h post BrdU injection and in microexplant cultures

abnormal neuron proliferation ( J:164148 )

• increase in the proliferation of granule cell precursors at P0 and P6

abnormal cerebellum external granule cell layer morphology ( J:164148 )

• thicker than in controls at P0 - P9

• however, by P18 the EGL has disappeared in both mutants and controls

abnormal Purkinje cell dendrite morphology ( J:164148 )

• impairment in dendritic arborization resulting in stunted arbors is seen at P6 and in adults

• the distance between the tip of the soma and the points of branching is decreased

thin cerebellar molecular layer ( J:164148 )

• in adults

behavior/neurological

impaired coordination ( J:164148 )

• fall off a rotarod sooner than controls

abnormal gait ( J:164148 )

• larger stride length and width and significantly less overlap between front and hind footprints

long stride length ( J:164148 )

cellular

abnormal cerebellar granule cell migration ( J:164148 )

• a delay in migration is detected 72 - 96 h post BrdU injection and in microexplant cultures

abnormal neuron proliferation ( J:164148 )

• increase in the proliferation of granule cell precursors at P0 and P6