About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Actbtm1(INSR)Dac
targeted mutation 1, Dominico Accili
MGI:4831148
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac
Tg(Hsp70-1-cre)6Arge/? 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA MGI:4831153
cn2
 		Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac
Tg(Syn1-cre)671Jxm/? 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA MGI:4831155
cn3
 		Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac
Tg(Nes-cre)1Kln/? 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * SJL MGI:4831154
cn4
 		Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac
Tg(Camk2a-cre)#Szi/? 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J * CBA MGI:4831152
cx5
 		Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:4831156


Genotype
MGI:4831153
cn1
Allelic
Composition		 Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac
Tg(Hsp70-1-cre)6Arge/?
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actbtm1(INSR)Dac mutation (0 available); any Actb mutation (53 available)
Insrtm1Dac mutation (2 available); any Insr mutation (95 available)
Tg(Hsp70-1-cre)6Arge mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:91350 )
• die between 6 and 8 weeks

homeostasis/metabolism
increased circulating glucose level ( J:91350 )
• diabetic in one week
increased circulating insulin level ( J:91350 )
• extremely elevated




Genotype
MGI:4831155
cn2
Allelic
Composition		 Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac
Tg(Syn1-cre)671Jxm/?
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actbtm1(INSR)Dac mutation (0 available); any Actb mutation (53 available)
Insrtm1Dac mutation (2 available); any Insr mutation (95 available)
Tg(Syn1-cre)671Jxm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:91350 )
• die between 6 and 8 weeks

homeostasis/metabolism
increased circulating glucose level ( J:91350 )
• diabetic in one week
increased circulating insulin level ( J:91350 )
• extremely elevated




Genotype
MGI:4831154
cn3
Allelic
Composition		 Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac
Tg(Nes-cre)1Kln/?
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actbtm1(INSR)Dac mutation (0 available); any Actb mutation (53 available)
Insrtm1Dac mutation (2 available); any Insr mutation (95 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:91350 )
• die between 6 and 8 weeks

homeostasis/metabolism
increased circulating glucose level ( J:91350 )
• diabetic in one week
increased circulating insulin level ( J:91350 )
• extremely elevated




Genotype
MGI:4831152
cn4
Allelic
Composition		 Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac
Tg(Camk2a-cre)#Szi/?
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actbtm1(INSR)Dac mutation (0 available); any Actb mutation (53 available)
Insrtm1Dac mutation (2 available); any Insr mutation (95 available)
Tg(Camk2a-cre)#Szi mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:91350 )
• die between 6 and 8 weeks

homeostasis/metabolism
increased circulating glucose level ( J:91350 )
• diabetic in one week
increased circulating insulin level ( J:91350 )
• extremely elevated




Genotype
MGI:4831156
cx5
Allelic
Composition		 Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actbtm1(INSR)Dac mutation (0 available); any Actb mutation (53 available)
Insrtm1Dac mutation (2 available); any Insr mutation (95 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:91350 )
• die within a few days of birth

homeostasis/metabolism
increased circulating ketone body level ( J:91350 )
• diabetic ketosis
• cause of early death




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory