All Phenotypes Serpina6<tm1.1Mmp> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Serpina6^tm1.1Mmp/Serpina6^tm1.1Mmp	involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL	MGI:4833684
ht2	Serpina6^tm1.1Mmp/Serpina6⁺	involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL	MGI:4833685

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:164345 )

N	• mice exhibit normal behavior in an elevated plus maze and open field

impaired behavioral response to cocaine ( J:164345 )

• cocaine-treated mice fail to exhibit a locomotor response sensitization unlike similarly treated wild-type mice

behavioral despair ( J:164345 )

• during sessions of inescapable footshock, mice exhibit increased learned helplessness escape failures and increased learned helplessness avoidance compared with similarly treated wild-type mice

• in a forced-swim test, mice exhibit increased level of immobility compared with similarly treated wild-type mice

homeostasis/metabolism

abnormal circulating corticosterone level ( J:164345 )

• morning, but not evening, concentrations of free corticosterone is greater than in wild-type mice

• stressed mice exhibit decreased free plasma corticosterone compared with similarly treated wild-type mice

• however, total corticosterone levels are normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
corticosteroid-binding globulin deficiency		DOID:0090030	OMIM:611489	J:164345 , J:192931

Allelic Composition	Serpina6^tm1.1Mmp/Serpina6⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Serpina6^tm1.1Mmp mutation (0 available); any Serpina6 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype