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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nusap1tm1.1Gcm
targeted mutation 1.1, Geert Carmeliet
MGI:4833676
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nusap1tm1.1Gcm/Nusap1tm1.1Gcm involves: 129/Sv * Swiss MGI:4833677


Genotype
MGI:4833677
hm1
Allelic
Composition
Nusap1tm1.1Gcm/Nusap1tm1.1Gcm
Genetic
Background
involves: 129/Sv * Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nusap1tm1.1Gcm mutation (0 available); any Nusap1 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygous embryos are present in expected numbers at E3.5
• no homozygous embryos at E10.5
• embryonic death around the time of implantation

embryo
• E3.5 embryos cultured in vitro for 3 days contain extensive apoptotic cells
• smaller than controls after E3.5
• internal embryonic structure is disorganized subsequent to E3.5
• inner cell mass is reduced after E3.5

cellular
• mitotic cells are mostly in prometaphase (72%)
• chromosomes remain dispersed in cytoplasm
• spindle structures are distorted
• increased number of mitotic cells
• E3.5 embryos cultured in vitro for 3 days contain extensive apoptotic cells

growth/size/body
• smaller than controls after E3.5





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory