Phenotypes associated with this allele

• Allele Symbol: Tg(Pomc)#Low
• Allele Name: transgene insertion, Malcolm J Low
• Allele ID: MGI:4833830
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Pomc^tm1Low/Pomc^tm1Low Tg(Pomc)#Low/0	involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster	MGI:4833835
cx2	Pomc^tm1Low/Pomc^+ Tg(Pomc)#Low/0	involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster	MGI:4833836
cx3	Pomc^tm1Low/Pomc^tm1Low Tg(Pomc)#Low/Tg(Pomc)#Low	involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster	MGI:4833837
tg4	Tg(Pomc)#Low/0	involves: C57BL/6 * DBA/2	MGI:4833838

Genotype
MGI:4833835

cx1

• Allelic Composition: Pomc^tm1Low/Pomc^tm1Low; Tg(Pomc)#Low/0
• Genetic Background: involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased pituitary adenoma incidence ( J:119240 )

• melanotroph adenomas

mortality/aging

mortality/aging ( J:119240 )

N • mice exhibit normal survival perinatally

homeostasis/metabolism

increased circulating adrenocorticotropin level ( J:119240 )

• in unstressed male mice

abnormal corticosterone level ( J:119240 )

• male mice exhibit an abnormal corticosterone secretion pattern with exaggerated nadir and peak levels compared with wild-type mice

• however, corticosterone secretion pattern in female mice is normal

increased circulating corticosterone level ( J:119240 )

• in male mice

decreased adrenocorticotropin level ( J:119240 )

• in the hypothalamus

• however, expression is restored in the pituitary

decreased circulating adrenocorticotropin level ( J:119240 )

• in male and female mice under acute restrain stress

endocrine/exocrine glands

increased adrenal gland zona fasciculata size ( J:119240 )

• the zona fasciculata is hypertrophic with increased volume of eosinophilic cytoplasm per cell and decreased numbers of cells per high-power field compared to in wild-type mice

enlarged adrenal glands ( J:119240 )

• greater in male than female mice

increased pituitary adenoma incidence ( J:119240 )

• melanotroph adenomas

growth/size/body

increased body weight ( J:119240 )

neoplasm

increased pituitary adenoma incidence ( J:119240 )

• melanotroph adenomas

Genotype
MGI:4833836

cx2

• Allelic Composition: Pomc^tm1Low/Pomc⁺; Tg(Pomc)#Low/0
• Genetic Background: involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster

neoplasm

increased pituitary adenoma incidence ( J:119240 )

• melanotroph adenomas

nervous system

increased pituitary adenoma incidence ( J:119240 )

• melanotroph adenomas

endocrine/exocrine glands

increased pituitary adenoma incidence ( J:119240 )

• melanotroph adenomas

Genotype
MGI:4833837

cx3

• Allelic Composition: Pomc^tm1Low/Pomc^tm1Low; Tg(Pomc)#Low/Tg(Pomc)#Low
• Genetic Background: involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster

growth/size/body

increased body weight ( J:119240 )

• compared with Tg(Pomc)#Low homozygotes

homeostasis/metabolism

increased circulating corticosterone level ( J:119240 )

• compared with Tg(Pomc)#Low homozygotes

Genotype
MGI:4833838

tg4

• Allelic Composition: Tg(Pomc)#Low/0
• Genetic Background: involves: C57BL/6 * DBA/2

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:119240 )

N • mice exhibit normal adrenal gland weight

growth/size/body

growth/size/body region phenotype ( J:119240 )

N • mice exhibit normal body weight

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:119240 )

N • mice exhibit normal basal corticosterone levels