About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trip10tm1.1Geha
targeted mutation 1.1, Raif S Geha
MGI:4834223
Summary 2 genotypes


Genotype
MGI:4834264
hm1
Allelic
Composition		 Trip10tm1.1Geha/Trip10tm1.1Geha
Genetic
Background		 B6.129S1-Trip10tm1.1Geha
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trip10tm1.1Geha mutation (0 available); any Trip10 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal spleen germinal center morphology ( J:164363 )
• following exposure to Keyhole Limpet hemocyanin (KLH), spleens exhibit less numerous and less prominent germinal centers with a reduced percent of B220+IgDloFas+GL7+ B cells compared to in similarly treated wild-type mice
• however, the density of CD3+ cells is normal
decreased spleen germinal center number ( J:164363 )
• following exposure to Keyhole Limpet hemocyanin (KLH)
decreased spleen germinal center size ( J:164363 )
• following exposure to Keyhole Limpet hemocyanin (KLH)
decreased IgE level ( J:164363 )
• following exposure to Keyhole Limpet hemocyanin (KLH)
decreased IgG level ( J:164363 )
• following exposure to Keyhole Limpet hemocyanin (KLH)
abnormal T cell physiology ( J:164363 )
• T cells exhibit defective adhesion to integrin and endothelial cells with impaired transepithelial migration compared with wild-type cells
decreased susceptibility to type IV hypersensitivity reaction ( J:164363 )
• mice sensitized to oxazalone exhibit less ear swelling, cellular infiltration, and edema compared with similarly treated wild-type mice
• lymph node cells transferred into wild-type mice do not confer the ability to mount a contact hypersensitivity response unlike when wild received wild-type cells
• however, dendritic cell mobilization is normal

hematopoietic system
abnormal spleen germinal center morphology ( J:164363 )
• following exposure to Keyhole Limpet hemocyanin (KLH), spleens exhibit less numerous and less prominent germinal centers with a reduced percent of B220+IgDloFas+GL7+ B cells compared to in similarly treated wild-type mice
• however, the density of CD3+ cells is normal
decreased spleen germinal center number ( J:164363 )
• following exposure to Keyhole Limpet hemocyanin (KLH)
decreased spleen germinal center size ( J:164363 )
• following exposure to Keyhole Limpet hemocyanin (KLH)
decreased IgE level ( J:164363 )
• following exposure to Keyhole Limpet hemocyanin (KLH)
decreased IgG level ( J:164363 )
• following exposure to Keyhole Limpet hemocyanin (KLH)
abnormal T cell physiology ( J:164363 )
• T cells exhibit defective adhesion to integrin and endothelial cells with impaired transepithelial migration compared with wild-type cells




Genotype
MGI:4834266
cx2
Allelic
Composition		 Tg(TcraTcrb)425Cbn/0
Trip10tm1.1Geha/Trip10tm1.1Geha
Genetic
Background		 B6.Cg-Trip10tm1.1Geha Tg(TcraTcrb)425Cbn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcraTcrb)425Cbn mutation (3 available)
Trip10tm1.1Geha mutation (0 available); any Trip10 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:164363 )
N
• oxazalone-treated mice exhibit normal antigen-specific T effector cell generation
abnormal effector T cell morphology ( J:164363 )
• following ovalbumin skin-challenge, effector T cells exhibit a 10-fold reduction in accumulation compared to when wild-type cells are transferred
decreased CD4-positive, alpha-beta T cell number ( J:164363 )
• accumulation of CD4+ T cells in ovalbumin-challenged ears of wild-type recipient mice is impaired compared to when wild-type cells are used

hematopoietic system
abnormal effector T cell morphology ( J:164363 )
• following ovalbumin skin-challenge, effector T cells exhibit a 10-fold reduction in accumulation compared to when wild-type cells are transferred
decreased CD4-positive, alpha-beta T cell number ( J:164363 )
• accumulation of CD4+ T cells in ovalbumin-challenged ears of wild-type recipient mice is impaired compared to when wild-type cells are used




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory