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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trip10tm1.1Geha
targeted mutation 1.1, Raif S Geha
MGI:4834223
Summary 2 genotypes


Genotype
MGI:4834264
hm1
Allelic
Composition		 Trip10tm1.1Geha/Trip10tm1.1Geha
Genetic
Background		 B6.129S1-Trip10tm1.1Geha
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trip10tm1.1Geha mutation (0 available); any Trip10 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal spleen germinal center morphology ( J:164363 )
• following exposure to Keyhole Limpet hemocyanin (KLH), spleens exhibit less numerous and less prominent germinal centers with a reduced percent of B220+IgDloFas+GL7+ B cells compared to in similarly treated wild-type mice
• however, the density of CD3+ cells is normal
decreased spleen germinal center number ( J:164363 )
• following exposure to Keyhole Limpet hemocyanin (KLH)
decreased spleen germinal center size ( J:164363 )
• following exposure to Keyhole Limpet hemocyanin (KLH)
decreased IgE level ( J:164363 )
• following exposure to Keyhole Limpet hemocyanin (KLH)
decreased IgG level ( J:164363 )
• following exposure to Keyhole Limpet hemocyanin (KLH)
abnormal T cell physiology ( J:164363 )
• T cells exhibit defective adhesion to integrin and endothelial cells with impaired transepithelial migration compared with wild-type cells
decreased susceptibility to type IV hypersensitivity reaction ( J:164363 )
• mice sensitized to oxazalone exhibit less ear swelling, cellular infiltration, and edema compared with similarly treated wild-type mice
• lymph node cells transferred into wild-type mice do not confer the ability to mount a contact hypersensitivity response unlike when wild received wild-type cells
• however, dendritic cell mobilization is normal

hematopoietic system
abnormal spleen germinal center morphology ( J:164363 )
• following exposure to Keyhole Limpet hemocyanin (KLH), spleens exhibit less numerous and less prominent germinal centers with a reduced percent of B220+IgDloFas+GL7+ B cells compared to in similarly treated wild-type mice
• however, the density of CD3+ cells is normal
decreased spleen germinal center number ( J:164363 )
• following exposure to Keyhole Limpet hemocyanin (KLH)
decreased spleen germinal center size ( J:164363 )
• following exposure to Keyhole Limpet hemocyanin (KLH)
decreased IgE level ( J:164363 )
• following exposure to Keyhole Limpet hemocyanin (KLH)
decreased IgG level ( J:164363 )
• following exposure to Keyhole Limpet hemocyanin (KLH)
abnormal T cell physiology ( J:164363 )
• T cells exhibit defective adhesion to integrin and endothelial cells with impaired transepithelial migration compared with wild-type cells




Genotype
MGI:4834266
cx2
Allelic
Composition		 Tg(TcraTcrb)425Cbn/0
Trip10tm1.1Geha/Trip10tm1.1Geha
Genetic
Background		 B6.Cg-Trip10tm1.1Geha Tg(TcraTcrb)425Cbn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcraTcrb)425Cbn mutation (3 available)
Trip10tm1.1Geha mutation (0 available); any Trip10 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:164363 )
N
• oxazalone-treated mice exhibit normal antigen-specific T effector cell generation
abnormal effector T cell morphology ( J:164363 )
• following ovalbumin skin-challenge, effector T cells exhibit a 10-fold reduction in accumulation compared to when wild-type cells are transferred
decreased CD4-positive, alpha-beta T cell number ( J:164363 )
• accumulation of CD4+ T cells in ovalbumin-challenged ears of wild-type recipient mice is impaired compared to when wild-type cells are used

hematopoietic system
abnormal effector T cell morphology ( J:164363 )
• following ovalbumin skin-challenge, effector T cells exhibit a 10-fold reduction in accumulation compared to when wild-type cells are transferred
decreased CD4-positive, alpha-beta T cell number ( J:164363 )
• accumulation of CD4+ T cells in ovalbumin-challenged ears of wild-type recipient mice is impaired compared to when wild-type cells are used




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory