Phenotypes associated with this allele

• Allele Symbol: Tardbp^tm1.2Pcw
• Allele Name: targeted mutation 1.2, Philip C Wong
• Allele ID: MGI:4834280
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tardbp^tm1.2Pcw/Tardbp^tm1.2Pcw	involves: C57BL/6 * SJL	MGI:4834586

Genotype
MGI:4834586

hm1

• Allelic Composition: Tardbp^tm1.2Pcw/Tardbp^tm1.2Pcw
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:164406 )

• no live-born homozygous animals were recovered in litters from 10 intercrosses of heterozygous mice

• in culture, after 3 days of tamoxifen treatment, ES cells carrying one floxed allele of Tardbp and one null allele expressing tamoxifen-inducible cre recombinase exhibit a reduction in proliferation (colony size) and increase apoptosis, compared to control ES cells with one functional Tardbp allele, with the differences increased by day 9 after induction; these results indicate that Tardbp is essential for ES cell survival and possibly embryonic survival of homozygous embryos